Theophylline Choline theophyllinate

Others. Other choline salts available as commercial products include choline bicarbonate [78-73-9] choline saUcylate [2016-36-6] and the bronchodilator choline theophyllinate [4499-40-5]. 

Therapeutic Function Smooth muscle relaxant Chemical Name Theophylline cholinate Common Name Oxotriphylline oxytrimethylline... 

IB parts by weight of theophylline are added to 37.8 parts by weight of aqueous choline bicarbonate (47% assay) and the mixture stirred and heated at B0°C to 90°C until the evolution... 

Choline theophyllinate Choline chloride Carbachol Choline salicylate Choline dihydrogen citrate Ferrocholinate Chromic acid... 

When Hie cholinesterase inhibitors are administered with the anticholinergic drugp, there is a potential decrease in activity of the anticholinergic drug. There is an increased risk of toxicity of theophylline when the cholinesterase inhibitors are administered with tacrine There is a synergistic effect when tacrine is administered with succinyl-choline, cholinesterase inhibitors, or cholinergic agonists (eg, bethanechol). 

Mechanism of Action A choline salt of theophylline which acts as a bronchodilator by directly relaxing smooth muscle of the bronchial airway and pulmonaryblood vessels. T herapeuticEffect Relieves bronchospasm, increases vital capacity. Produces cardiac skeletal muscle stimulation. 

Caffeine is used medicinally as a CNS stimulant, usually combined with another therapeutic agent, as in compound analgesic preparations. Theobromine is of value as a diuretic and smooth muscle relaxant, but is not now routinely used. Theophylline is an important smooth muscle relaxant for relief of bronchospasm, and is frequently dispensed in slow-release formulations to reduce side-effects. It is also available as aminophylline (a more soluble preparation containing theophylline with ethylenediamine) and choline theophyllinate (theophylline and choline). The alkaloids may be isolated from natural sources, or obtained by total or partial synthesis. 

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