Thematic analysis

In the BioFocus approach, the analysis was driven by the observed SAR of the systems and in the above case by some elegant experimental biology. More formally Thematic Analysis is a superset of the above approach as it describes the recognition processes in all-hehcal environments and hence is able to be extended to Family B and C GPCRs and also ion channels. 

However, Thematic Analysis does not require an accurate description of the binding domain only that a consistent consensus binding domain exists. The assumption was made, therefore, that this does exist and is defined, as for Family A, by the upper portions of transmembrane helices. " This is not unreasonable as the transduction mechanisms responsible for the interactions with the G-proteins appear to involve the bottom parts of the helices of all GPCRs. It is presumed that the shape and size of the consensus-binding domain is different between the families but is consistent within a family. 

Experience across a wide variety of receptors with the screening of libraries designed in this way demonstrates that these design principles are effective and hits have been foimd for receptors which otherwise were considered to be difficult. Hits at a particular receptor are usually found in clusters giving an early indication of the SAR, and the same design considerations, used to produce the library, can be used in the lead optimization process. The extension of Thematic Analysis into Families B and C opens up the possibility of obtaining tractable leads in these areas as well. 

Braun, V., Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3(2), 77-101. 

A thematic analysis of the issues identified on walk-rounds is routinely carried out to measure the completion rate. Trust data showed that the clear-up rate of high priority issues has improved year on year, in 2011, 50 percent of actions were resolved and 26 percent were partly resolved. 

Thematic analysis also showed that the most frequently identified issues are environmental - the physical space and design of the hospital accoimted for just over 25 percent of all issues identified, followed by equipment (23 percent) and clinical processes (20 percent). Many of these issues were unresolvable within the one month time frame set because they related to the environment in which healthcare teams work. They are therefore not easily fixed. 

We used primarily qualitative methods in our analysis of what makes employees feel maximally included. Qualitative analysis is an inquiry process of understanding a social or human problem based upon building a complex, holistic picture formed with words reporting detailed views of informants, and conducted in a natural setting. Also known as interpretive research, its foundation was built by late nineteenth-century writers such as Kant, Weber, and Dilthey For more information about qualitative approaches to research ingeneral, we recommend Hennink s 2004 book. We also recommend Boyatzis 2004 book on Thematic Analysis, which informed the analysis of the data presented in this book. 

Ward, V., House, A. and Hamer, S. (2009a). Developing a framework for transferring knowledge into action A thematic analysis of the literature. Journal of Health Services Research Policy, 14(3), pp. 156-164. 

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