The Query Menu

In addition to addressing the practicalities of database maintenance, we also aim to enhance the range of the facilities available, to make the information within CHIRBASE more readily accessible to users. CHIRBASE contains two form-based applications for query building designed to help novice or expert users to formulate queries the query menu and the automatic search tool. 

CHIRBASE provides integrated responses from single questions, as well as from combinatorial questions constructed on the basis of any specific query corresponding to one or several field(s) occurring in the database. With the molecular structure of a sample in hand, the search can be conducted interactively from the query menu form. 

The query menu is simple to use for answering most of the questions commonly addressed to the database ... 

Fig. 4-4. The query menu form seareh of ehiral separations of alpha-aromatie aeids on any polysae-eharide CSPs with a > 1.2.

The four Build Menus ia REACCS are Stmcture, Query, Top, and HighlightRxn. Stmcture menu contains the basic drawiag commands used to constmct the backbone of the stmcture. Query menu contains the commands used to add flexible stmctural parameters to the query. Top menu contains commands used to build reactions and to store and retrieve reactions, molecules, and graphic queries. HighlightRxn menu contains commands that apply atom/atom mapping and reaction centers to the current reaction. Atom/atom mapping is used to identify the reaction centers and iacrease accuracy and efficiency by letting the searcher specify that a particular atom ia a reactant must correspond to a particular atom ia the product. 

The "Query Result Archive" function provides tables of results from recent analyses so that the user can readily see differences between closely related specimens. The "Load Calibration Function" entry in the Data Handling Menu allows the user to change calibration functions to suit his particular needs. 

Choose one of these by typing the corresponding menu letter [a,b,c,d,e,f]] a Figure 2, Queries for the Module Detector. 

PROSITE is a database of biologically significant sites and patterns (amino acid residues) formulated from a known family of proteins as the characteristic familial identifiers or signatures that can be used to detected such family from the query sequences of proteins. If the PROSITE database (prosite.dat downloaded from http //expasy.hcuge.ch/sprot/prosite.html) is installed in the usrstuff directory, selecting Search for PROSITE tool from the Edit menu returns a list of ProSite for... 

The help menu opens up a long list of issues that the designer can find assistance with, as shown in Figure 10.11. Additionally, several of the program inputs allow the designer to double click on the input query and information about that issue will pop up on the screen. 

Select the data points option in the output format menu, then click the get output button (see Note 13). The Table Browser displays the conservation scores for each base in the selected region of the reference sequence. To save these data to a file, type a file name into the output file text box and select the desired file type returned option prior to running the query. Click the Tables link to return to the main Table Browser page. 

Even with the advent of interactive menu-driven query construction (see Section 3.5.8 below), it is still advisable to draw the required fragment carefully on paper and to consider the query definition under the following four subheadings. 

The user who selects C is offered a sketchpad (Figure 5) to input the query structure which is stored as part of the overall question. On exiting from the Search Definition Menu the user is returned to the Main Search Menu. Selection of S then effects the search. The results can be viewed or printed using options in V . 

A graphic-oriented interpreter has been designed to control the input of the query structures, the retrieval procedure and the presentation of the answers. This software technology enables the user to customise the menu and to introduce new commands. A hierarchic multiwindow technique facilitates the construction of complex Markush queries. 

Our full structure search system determines the possible Chemical Abstracts Service (CAS) registry numbers and internal compound numbers for a given structural drawing. Additionally the user can select from a set of predefined keyword profiles and submit a job for CAS ONLINE. A minicomputer will set up the query, call the host system, perform the search, capture the answers and inform the user that the job was successfully completed. The user can now play back the answers at his terminal with structural formulae, bibliography and abstracts. The only activities are structure drawing, menu selection, waiting and scanning the results. 

The selected sequence and the query sequence can be seen in models and templates division by default. The template sequence can be changed by clicking the drop-down menu and multiple sequences can also be selected. Specify the path for the output model to be saved by clicking on browse. The rotamer library and... 

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