The M-T7 Protein Encoded by Myxoma Virus MYXV

Myxomatosis is a severe disease of European rabbits that is caused by MYXV. Initial work identified the MYXV M-T7 gene encodinga 37-kDa glycoprotein that is abundandy secreted fiom infected cells. The M-T7 ORE showed significant similarity to the extracellular bindii domain of human and mouse interferon-y receptors (IFN-yRs) and was shown to bind to and inhibit the biological activity of rabbit IFN-y in a species specific manner.  

Pathogen Protein Species Binding Properties and Mechanism of Action Reference 

Poxvirus M-T7 MYXV Secreted, binds C, CC and CXC chemokines through GAG binding domain and IFN-y 14 

Herpesvirus M3 MHV-68 Secreted, binds CC, CXC, C and CX3C chemokines, blocks the interaction of chemokines with receptors and GAGs, and cell migration 52,53 

Parasites smCKBP Schistosoma mansoni Binds some CC, CXC and CX3C chemokines, expressed by schistosome eggs, block migration induced by chemokines 72 

---