The Glycal Assembly Method on Solid Supports Synthesis of Oligosaccharides and Glycoconjugates

The Glycal Assembly Method on Solid Supports Synthesis of Oligosaccharides and Glycoconjugates 

Boehringer Ingelheim Pharmaceuticals, Inc. Research and Development Center, 

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer 

Research, and Department of Chemistry, Columbia University, New York, New York 

The three major classes of biopolymers found in eukaryotic systems are nucleic acids, proteins, and polysaccharides. The latter class is the most complex with respect to structural and stereochemical diversity. Polysaccharides indeed possess a massive information content. Furthermore, polysaccharides are commonly found in nature covalently attached (conjugated) to other biomolecules such as proteins, isoprenoids, fatty acids, and lipids.1 

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