Glycal assembly method

Glycal assembly method (Section 25.11) A method for linking monosaccharides together to sym thesis polysaccharides. 

Glycal assembly method, 1002 (4- )-Glyceraldehyde. absolute configuration of, 980 (-)-Glyceraldehyde, configuration of, 300... 

The Glycal Assembly Method on Solid Supports Synthesis of Oligosaccharides and Glycoconjugates... 

Scheme 2.2 General strategy for the synthesis of oligosaccharides on a solid support using the glycal assembly method.

Seeberger, P. H. Bilodeau, M. T. Danishefsky, S. J. Synthesis of Biologically Important Oligosaccharides and Other Glycoconjugates by the Glycal Assembly Method, Aldrichim. Acta 1997, 30, 75. 

An early example of the 1,2-participation-migration strategy termed the glycal assembly method was developed by Samuel Danishefsky and coworkers (Scheme 4.5a) [22], In this approach, the double bond of a glycal is converted into an epoxide or... 

Glycal assembly method (Section 25.9) a method of polysaccharide synthesis in which a glycal is converted into its epoxide, which is then opened by reaction with an alcohol. 

Seeberger PH, Bilodeau MT, Danishefsky SJ. Synthesis of biologically important oligosaccharides and other glycoconjugates by the glycal assembly method. Aldrichim. Acta. 1997 30 75-92. Gin D. Dehydrative glycosylation with 1-hydroxy donors. J. Carb. Chem. 2002 21 33-52. 

With numerous -OH groups of similar reactivity, polysaccharides are so structurally complex that their laboratory synthesis has been a particular difficult problem. Several methods are now under development, however, that appear poised to revolutionize the field. Among the most promising of these new approaches is the glycal assembly method. 

Scheme 3 Solid phase synthesis of a hexasaccharide by the glycal assembly method.

---