Glycal assembly

Glycal assembly method (Section 25.11) A method for linking monosaccharides together to sym thesis polysaccharides. 

Glycal assembly method, 1002 (4- )-Glyceraldehyde. absolute configuration of, 980 (-)-Glyceraldehyde, configuration of, 300... 

The Glycal Assembly Method on Solid Supports Synthesis of Oligosaccharides and Glycoconjugates... 

Scheme 2.2 General strategy for the synthesis of oligosaccharides on a solid support using the glycal assembly method.

SOLID SUPPORT GLYCAL ASSEMBLY VIA 1,2-ANHYDROSUGAR DONORS... 

Scheme 2.7 Oligosaccharides assembled on solid phase via glycal assembly. The asterisk denotes the achorage site of the first glycal to the solid support via SiPtfe linker.

Glycal assembly on a solid support eliminates the repetitive purifications usually associated with oligosaccharide synthesis. As a method, it has a certain generality as it does not require any specific enzymes or complex starting materials. Both natural and nonnatural sugars may be used in the constructions. 

The convergent synthesis of glycopeptides in which the carbohydrate moiety is attached to the solid support proved an efficient alternative methodology.64 The carbohydrate structure itself was synthesized on solid support via glycal assembly and anomeric amine synthesis (Scheme 13.20). 

Scheme 13.20 Solid-phase glycal assembly and anomeric amine synthesis.

Seeberger, P. H. Bilodeau, M. T. Danishefsky, S. J. Synthesis of Biologically Important Oligosaccharides and Other Glycoconjugates by the Glycal Assembly Method, Aldrichim. Acta 1997, 30, 75. 

Carbohydrates play an important role in nature. This chapter shows that the glycal assembly strategy can be used to synthesize complex carbohydrates. 

An early example of the 1,2-participation-migration strategy termed the glycal assembly method was developed by Samuel Danishefsky and coworkers (Scheme 4.5a) [22], In this approach, the double bond of a glycal is converted into an epoxide or... 

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