Tetrahydroquinoline combinatorial synthesis

Polymeric catalysts. A very useful modification of the catalyst is obtained by ligand exchange with a (polyallyl)triflamide, forming polymer-bound scandium triflamide bistriflate. The catalyst has been used in the combinatorial synthesis of a tetrahydroquinoline library from anilines, aldehydes, and alkenes. A related catalyst prepared from ScClj-bHjO and Nafion is effective in several useful synthetic reactions, including allylation, Diels-Alder reaction, and Friedel-Crafts acylation. ... 

The three component condensation employing aldehydes, anilines and electron-rich olefins leading to substituted tetrahydroquinolines 93 constitutes an attractive approach for combinatorial and parallel synthesis (Scheme 3.6.13). 

A powerful tool to synthesize easily minute amounts of organic compounds on demand by using both ionic liquids droplets as microreactors and electrowetting as a fluidic motor has been described. These droplets can be moved, divided and combined on an open digital microfluidic lab-on-a-chip system [60]. This has been demonstrated with BTS ILs used as reaction media and supports, properly functionalized to perform the Grieco s multicomponent synthesis of tetrahydroquinolines (Fig. 5.5-3). It is assumed that this original concept should impact many areas, notably combinatorial chemistry, parallel synthesis, optimization of protocols, synthesis of dangerous products and embedded chemistry in a portable device. 

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