Tetracycline Theophylline

The following agents may be affected by theophylline Benzodiazepines, -agonists, halothane, ketamine, lithium, nondepolarizing muscle relaxants, propofol, ranitidine, and tetracyclines. Probenecid may increase the effects of dyphylline. 

Drugs that may be affected by tetracyclines include oral anticoagulants, digoxin, insulin, isotretinoin, methoxyflurane, oral contraceptives, penicillins, and theophyllines. 

Hard capsules are used for powdered drugs e.g. capsules ampicillin, tetracycline. In hard capsules, certain sustained released substance, which gradually release the drug in the respiratory tract (e.g. cap. theophylline). 

Dehydrations are chemical reactions that involve the loss of water. The acid-catalyzed dehydration of tetracycline yields the toxic epianhydrotetracycline [20]. The physical dehydration of theophylline hydrate and ampicillin trihydrate leads to a change of the crystalline structure of the drug [21]. 

Cimetidine Phenytoin Ciprofloxacin Ranitidine Digoxin Tetracycline Norfloxacin Theophylline... 

MIP membranes were prepared for the recognition of water soluble L-glutamine [218], tetracycline [221], uric acid [223], theophylline [216, 222] and naringin... 

Composite MIP membranes can also be obtained by incorporation of MIP particles into the membrane polymer matrix by mixing the particles in an appropriate solvent with the membrane-forming polymer that is then solidified by the phase inversion process. Membranes thus prepared were used for separation, with targets such as tetracycline [257], theophylline [255], methylphosphonic acid [258], bisphenol [259], indole derivatives [260], propanolol [261], luteolin [262] and norfloxacin... 

Tetracycline Tetracycline injections have an acid pH. Incompatibility may reasonably be expected with alkaline preparations or with drugs unstable at low pH. Care should be taken when administering tetracyclines, since chelation takes place with metal ions. Tetracyclines interact with inorganic metal ions. They should not be used with drugs that cause hepatotoxicity and nephrotoxicity (e.g., digoxin, theophylline, ergot alkaloids, methotrexate, oral contraceptives, and penicillins). 

Aminophylline Aminophylline should not be mixed with acidic drugs, as it becomes precipitated if the pH of the final solution falls below pH 8. Mixture with glucose may increase the pH above 10 where proteins, such as insulin and erythromycin, are unstable. Some drugs that are incompatible with aminophylline include amiodarone, benzylpenicillin potassium, cisatracurium, ceftazidime, ceftriaxone, dobutamine, tetracycline hydrochloride, verapamil hydrochloride, warfarin sodium, and vitamin B and C injection. Alcohol-free theophylline should be stored in amber-colored containers maximum care must be taken to protect it against exposure to light.92-94... 

In this context, amidic- " " as well as hydroxamic acid Mannich bases of well-known drugs, such as tetracyclines, indometacine, etc., have been investigated along with model compounds. The N-hcterocyclic derivatives of theophylline, mercap-topurinc, etc., and the bisulfite Mannich bases, particularly interesting as diuretics (sec 520, Table 38), have been similarly studied. 

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