Tetracycline outdated

Outdated products Under no circumstances should outdated tetracyclines be administered the degradation products of tetracyclines are highly nephrotoxic and have, on occasion, produced a Fanconi-like syndrome. 

Renal tubular acidosis and other renal injury resulting in nitrogen retention have been attributed to the administration of outdated tetracycline preparations. Tetracyclines given along with diuretics may produce nitrogen retention. Tetracyclines other... 

Acquired Lignac-De Toni-Fanconi syndrome, with polyuria, polydipsia, glycosuria, aminoaciduria, hyper-phosphaturia, and hypercalciuria, was described in a number of patients treated with outdated tetracycline formulations. The degeneration products responsible for the toxic action are probably epitetracycline, anhydro-4-epitetracycline, and anhydrotetracycline (117), as similar renal damage was produced in rats with anhydro-4-epite-tracycline (118). 

Acute tubular necrosis (exogenous toxins) Aminoglycosides, amphotericin, cisplatin, radiocontrast agents, methoxyflurane, outdated tetracyclines, cephalosporins, mithramycin, calcineurin inhibitors, pentamidine, IVIG, ifosfamide, zoledronate, cidofovir, adefovir, tenofovir FENa>2%, UOsm <350, urinary sediment contains granular casts, renal epithelial cells... 

Tetracyclines Tetracyclines are broad spectrum antibiotics obtained from Streptomyces strains or prepared semisynthetically. Use of tetracyclines has resulted in three types of renal effects. First, the use of outdated tetracyclines results in direct proximal tubular toxicity characterized by the increased excretion of amino acids, glucose, and phosphate (Fan-coni syndrome). The mechanism of this response is unclear, but appears to be due to the formation of the degradation product anhydro-4-epi-tetracycline. Second, administration of some tetracyclines, particularly demeclocycline, can result in a dose-dependent, reversible nephrogenic diabetes insipidus, which appears to result from an inhibition of ADH effects on water reabsorption. Lastly, in patients with preexisting compromised renal function, tetracyclines can induce increased sodium excretion and azotemia. The mechanism of the naturesis may be due to an effect of tetracyclines on luminal membrane sodium conductance, while the azotemia appears to result from the antianabolic effects of the tetracyclines. 

Rena] toxicity One form of renal tubular acidosis, Fanconi s syndrome, has been attributed to use of outdated tetracyclines. Though not directly nephrotoxic, tetracyclines may exacerbate preexisting renal dysfunction. 

Hereditary Fructose Intolerance Outdated tetracyclines Bronchogenic carcinoma Drugs... 

A degradation product formed before the drug enters the body Outdated tetracycline... 

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