Tetracycline Dicumarol

Magnesium Oxide (Mag-Ox 400, Others) [OTC] [Antacid, Magnesium Supplement/Magnesium Salt] Uses R lace low Mg levels Action Mg supl Dose 400-800 mg/d daily-qid w/ full glass of HjO Caution [B, +] Contra UlcCTative colitis, diverticulitis, ileostomy/colostomy, heart block, renal insuff Disp Caps 140 mg tabs 400 mg (OTC) SE D, N Inter actions X Effects OF chlordiaz oxide, dicumarol, digoxin, indomethacin, INH, quinolones, tetracyclines EMS Monitor ECG for hypokalemia (flattened T waves) OD Unlikely to cause life-threatening Sxs, but may cause D, constipation, cramps, and abd pain symptomatic and supportive... 

Clinically important, potentially hazardous interactions with anisindione, anticoagulants, atracurium, cisatracurium, demeclocycline, dicumarol, doxacurium, doxycycline, imipenem/cilastatin, methotrexate, minocycline, non-depolarizing muscle relaxants, oxytetracycline, pancuronium, rapacuronium, reteplase, tetracycline, warfarin... 

The bioavailability of different specimens of a poorly soluble drug, when given orally and measured by the rate of the rise of plasma levels, varies enormously because of differing particle sizes. This test has revealed important differences between different brands of aspirin, diphenylhydantoin, cardiac glycosides (especially digoxin), tetracyclines, chloramphenicol, and dicumarol. The remedy is, usually supersonically micronize the drug. 

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