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Test substance-chemical handling

Some GLP professionals consider positive control substances (i.e., those materials intended to validate responsiveness of the test system to a chemical or biological challenge) to also be reference substances, as opposed to control substances however, the point is somewhat moot as the FIFRA GLP Standards characterization and handling requirements are exactly the same for both control and reference substances. As with test and control substances, reference substances must be characterized (usually determination of purity and stability) according to the abbreviated GLP Standards (see next section). [Pg.155]

Safety of Reactive Chemicals and Pyrotechnics (Yoshida et al. 1995). Addresses both the hazardous properties of reactive chemicals and appropriate handling methods. Describes several test methods and the evaluation of fire and explosion hazards of reactive substances, including the impact of initiating events such as earthquakes. [Pg.25]

Feelings of depression can be a result of exposure to chemical substances, so don t just think that everything is apparently too much for you to handle. Try avoiding chemical substances as much as possible and see what effect it has on your joy of life It s also good to have your blood tested to see if any deficiencies have arisen, in magnesium for example (because this can definitely... [Pg.134]

Under the Industrial Safety and Health Law, unlike the Chemical Substances Control Law, all chemical substances including a chemical substance regulated by other laws, such as the Food Sanitation Law in lapan and the Pharmaceutical Affairs Law, and used exclusively for the purpose permitted by such laws must be notified. Notification of a substance is accepted if it shows a negative result for the test and the notification document is complete. On acceptance, the substance can be manufactured and / or imported. If the substance shows a positive result for the test, the competent authority requires that additional tests be performed, such as a chromosomal aberration test, and the provision to workers who handle the substance with the information on safety, handling methods and emergency measures for the substance described in a Material Safety Data Sheet (MSDS). [Pg.288]

There are important differences between scientists and regulators in how they can address scientific uncertainties and what sort of considerations and trade-offs are connected with their handling of identified uncertainties. Usually, in science the focus is on avoiding false positives.3 (A false positive means that you conclude that a specific chemical is hazardous even though it is in fact not). Identified uncertainties in science can be handled by performing additional testing before a final conclusion can be made on the properties of a chemical. A decision-maker on the other hand will always have to treat every substance as if its properties were known, regardless of scientific uncertainties. If she, for instance decides to take no action to reduce exposures, this would correspond to a standpoint that the substance has... [Pg.158]


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See also in sourсe #XX -- [ Pg.528 , Pg.529 ]




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