Tert-Amylamine

Aminouracil, a 155 2-Aminovaleric acid, a253 5-Amino valeric acid, a254 Amyl compounds, see Pentyl Amyl alcohol, p37 act-Amyl alcohol, ml53 sec-Amyl alcohol, p38 tert-Amyl alcohol, ml54 tert-Amylamine, d601... 

A similar series of reactions may be used to prepare tert.-amylamine. The fer/.-amylurea is produced in yields of 50-58%, fef/.-amylphthalimide in yields of 63-72%, and tert.-amylamine, b.p. 77-78°, in 87% yields (N. L. Drake and John Garman, private communication). 

Ammonolysis, 401 Ampoules, glass. 205 n-Amylamine, 413, 417 n-Amyl acetate, 383 -Amyl alcohol, 247, 249 n-Amylbenzene, 511, 517 n-Amyl borate, 305 n-Amyl bromide, 279 tao-Amyl bromide, 279 n-Amyl chloride, 273 tao-Amyl chloride, 273 tert.-Amyl chloride, 275 n-Amyl cyanide, 407, 408 Amylene, 239 n-Amyl fluoride, 272, 289 n-Amyl iodide, 288 n-Amyl nitrite, 302, 306... 

The sensitivity of the analysis for different amines obtained by Walle for DNP derivatives using the ECD is demonstrated in Table 5.8. It varies in the range 2—20 pg. The reaction yields studied for diethyl-, tert. -butyl-, n-amyl- and di-n-butylamines are almost quantitative the recovery of the extraction from an aqueous solution of diethyl-, isopropyl- and w-amylamines is also reported as being practically 100%. If this is the case with other amines also, the problem of quantitative analysis is thus made considerably easier. The extraction of amines with benzene prior to the derivatization makes possible their isolation from other substances that could react with the reagent (e.g., phenols, see p. 88) and make the analysis complicated. 

Aminothiarole n-Amy] acetate iso-Amvl acetate n-Atnyl alcohol 7-Amyl alcohol Inactive Amyl alcohol leo-Amy] alcohol sec-Amyl alcohol tert-Amyl alcohol n-Amylamine iso-Amylamine n-Amylbenzene iso-Amyl bromide iso-Amyl-n-butyrate iso-Amyl chlcu ide iso-Amyl cyanide iso-AmvIene Amylene bromide Aroylene chloride iso-Amyl ether iso-Amyl formate Amylidene chloride... 

A typical example for the significance of aliphatic amines in the pharmaceutical industry is the analysis of amylamine and tert-butylamine. Both amines are intermediates in the synthesis of a thromboxane antagonist, while tert-butyl-amine also serves as a counterion of drug components. Amylamine and tert-butylamine can be eluted with methanesulfonic acid from an lonPac CS14 cation exchanger and detected by suppressed conductivity, but different eluent concentrations are used to account for the different affinities of the two amines toward the stationary phase [462]. Moreover, amine retention can be controlled by a small amount of acetonitrile in the mobile phase. In both cases, it is fortunate that the respective drug components are soluble in water and thus can be... 

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