Terminal Group-Modified

The introduction of lipophilic Choi terminal groups modifies the solution properties of the polymer conjugates, enabling them to self-associate into ordered structures (e.g., Upid structure) [118,120,125]. Some of these conjugates are considered to be advantageous for the fabrication of drug delivery systems [119,121]. 

Constmction of multilayers requires that the monolayer surface be modified to a hydroxylated one. Such surfaces can be prepared by a chemical reaction and the conversion of a nonpolar terminal group to a hydroxyl group. Examples of such reactions are the LiAlH reduction of a surface ester group (165), the hydroboration—oxidation of a terminal vinyl group (127,163), and the conversion of a surface bromide using silver chemistry (200). Once a subsequent monolayer is adsorbed on the "activated" monolayer, multilayer films may be built by repetition of this process (Fig. 8). 

The two matrices in these cements are of a different nature an ionomer salt hydrogel and polyHEMA. For thermodynamic reasons, they do not interpenetrate but phase-separate as they are formed. In order to prevent phase separation, another version of resin glass polyalkenoate cement has been formulated by Mitra (1989). This is marketed as VitraBond, which we term a class II material. In these materials poly(acrylic acid), PAA, is replaced by modified PAAs. In these modified PAAs a small fraction of the pendant -COOH groups are converted to unsaturated groups by condensation reaction with a methacrylate containing a reactive terminal group. These methacrylates can be represented by the formula ... 

Several classes of non-covalent substrate based inhibitors have been reported, and are grouped below based on the nature of the C-terminal group interacting with the catalytic triad of the enzyme. The majority of the reported inhibitors are based on the N-terminal product of a modified substrate of the NS5A/5B cleavage side or to a lesser extent of the NS4A/4B substrate peptide. 

Lee et al. utilized the self-assembled layer of thiol group-modified protein A for the oriented immobilization of antibodies [64], An increased binding capacity was further observed. As another illustrative instance, a protein A-based orientation-controlled immobilization strategy for antibodies was proposed for the fabrication of a QCM immunosensor using nanometer-sized gold particles and amine-terminated PPF [65], Moreover, in recent years, there has emerged another oriented immobilization... 

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