Ten Berge

J.M.F. ten Berge, Orthogonal Procrustes rotation for two or more matrices. Psychometrika, 42 (1977)267-276... 

As described in Section 6.3, exponential scaling (Cnxt=k ten Berge et al. 1986) was used to derive exposure duration-specific values. 

Animal to Fluman Dosimetric Adjustment None applied, insufficient data Time Scaling Cn t=k, where n=l or 3. The concentration-exposure time relationship for many irritant and systemically acting vapors and gases may be described by Cnxt=k, where the exponent n ranges from 0.8 to 3.5 (ten Berge et al. 1986). 

Time scaling 2.73 ppmx60 min=163.8 ppm-min C1xt=k (ten Berge et al. 1986) (27.3 ppm)1 60 min=163.8 ppm-min regression analysis of the squirrel monkey lethality data suggested a near linear... 

The adjusted exposure value estimated to be the threshold level of AEGL-2 effects (12 ppm for 15 min) was then scaled to AEGL time frames using the Cn xt=k relationship (ten Berge et al. 1986). For relatively brief exposures (i.e., <4 h), the data for dimethylhydrazine implied a linear concentration-response relationship (C1 t=k), which was used for AEGL derivations. LC50 data on... 

Tamietti G, Valentino D (2006) Soil solarization as an ecological method for the control of Fusarium wilt of melon in Italy. Crop Prot 25 389-397. doi 10.1016/j.cropro.2005.07.002 Ten Berge HFM (1990) Heat and water transfer in bare topsoil and the lower atmosphere. Center Agric. Publ. Doc. (Pudoc), Wageningen... 

Rat and mouse lethality data from the well-conducted study of Zwart et al. (1990) also suggest that Haber s law is valid for phosgene. The study by ten Berge et al. (1986) has shown that the concentration-exposure-time relationship for many irritant and systemically acting vapors and gasses can be described by the relationship Cnxt=k. When the 10- to 60-min rat LC50 data are utilized in a linear regression analysis a value of the exponent, n, of 0.93 is obtained. The mouse 10- to 60-min lethality data yield a value of 1.3 for n. 

When data are lacking for desired exposure times, scaling across time may be based on the relationship between concentration and exposure duration (Cn xt=k) when a common end point is used (ten Berge et al. 1986). The end points for HCN are incapacitation and lethality. Regression analysis of the data of Sakurai (1989), using incapacitation concentrations for mice for the exposure durations of 5, 10, 20, and 30 min, results in a value for n of 1.6. Regression analysis of the incapacitation data of Purser et al. (1984) for monkeys for the time period of 8 to 19 min results in a value for n of 2.1 (Appendix A, Figure A-l). These studies were of relatively short duration. 

Wilschut A, Ten Berge WF, Robinson PJ, McKone TE (1995) Estimating skin permeation. The validation of five mathematical skin permeation models. Chemosphere 30 1275-1296. 

Patel H, ten Berge W, Cronin MTD (2002) Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption. Toxicol. In Vitro 16 299-317. 

Appeltnan, L.M., ten Berge, W.F., and Reuzel, P.G. Acute inhalation toxicity study of ammonia in rats with variable exposure periods, Am. Ind. Hyg. Assoc. J., 43(9) 662-665, 1982. 

Ten Berg K, Hoogeboom AJ, Wesby-van Swaaij E, et al Maternal occupational methyl ethyl ketone exposure and multiple congenital anomalies. Teratology 65(6) 326, 2002... 

Evelo, C.T.A., Oostendorp, J.G.M., Ten Berge, W.F. Borm, P.J.A. (1993) Physiologically based toxicokinetic modeling of 1,3-butadiene lung metabolism in mice becomes more important at low doses. Environ. Health Perspect., 101, 496-502... 

Bermond B, Surachno S, Lok A, ten Berge IJ, Plasmans B, Kox C, Schuller E, Schellekens PT, Hamel R. Memory functions in prednisone-treated kidney transplant patients, din Transplant 2005 19(4) 512-7. 

Bouman HJ, Parlak E, Van Werkum JWV, Breet NJ, Ten Cate H, Hackeng CM, Ten Berg JM, Taubert D (2009) Which platelet function test is suitable to monitor clopidogrel responsiveness A pharmacokinetic analysis on the active metabolite of clopidogrel. J Thromb Haemost 8 482—488... 

---