Temporary acceptable daily intake

No studies on teratology or reproduction are available. The lifetime feeding study in the rat provides additional information for evaluating an acceptable daily intake for man. This data supports proposal of the previous temporary acceptable daily intake to an acceptable daily intake [29-33]. 

A temporary acceptable daily intake for povidone has been set by the WHO at up to 25 mg/kg body-weight. ... 

The WHO has set a temporary acceptable daily intake for saccharin, including its calcium, potassium, and sodium salts, at up to 2.5 mg/kg body-weight. In the UK, the Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment (COT) has set an acceptable daily intake for saccharin and its calcium, potassium, and sodium salts (expressed as saccharin sodium) at up to 5 mg/kg body-weight. ... 

The WHO has set an estimated acceptable daily intake for sodium and calcium cyclamate, expressed as cyclamic acid, at up to llmg/kg body-weight. In Europe, a temporary acceptable daily intake for sodium and calcium cyclamate, expressed as cyclamic acid, has been set at up to 1.5mg/kg body-weight. 

In 1988, JMPR recommended that temporary acceptable daily intakes should not be allocated for new compounds and that an ADI should not be allocated in the absence of an adequate database (FAOAVHO, 1988). The monographs are published for all chemicals that are reviewed, regardless of whether an ADI is allocated. The data requirements are clearly specified for those chemicals with an inadequate database. The concept of the conditional acceptable daily intake, adopted by the 1969 JMPR, was limited to those compounds for which the use was at that time considered essential but for which the toxicological database was... 

Toxicity. Methylene chloride is widely used in paint strippers and several non-fatal and fatal cases of accidental inhalation have been reported. The maximum permissible atmospheric concentration is 200 ppm and the temporary estimated acceptable daily intake is up to 500 pg/kg. 

Safety the WHO has established a temporary estimated acceptable daily intake for octyl gallate at up to 0.1 mg/kg... 

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