Temporal tumour

DeUian, M. Helmlinger, G. Yuan, R Jain, R. K. Rluorescence ratio imaging of interstitial pH in solid tumours effect of glucose on spatial and temporal gradients. Br. J. Cancer 1996, 74, 1206-1215. 

Chaplin, D. J. and Hill, S. A. (1995) Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours. Br. J. Cancer 71,1210-1213. 

As with tumour spheroid production, multiarray chips were also used to produce hESC aggregates. An anisotropic ally etched mould in silicon was used as a template for pyramid-shaped PDMS wells for high-throughput production of aggregates (Fig. 17) [135]. These chips were used to generate spatially and temporally synchronised hESC aggregates, which can be used for further fundamental studies in early human development processes. Another method used PEG-coated wells... 

Utilized in monitoring tumour and exploring pathologies without unnecessary sacrifice of animals. This is particularly important when temporal series of data are required. 

A variety of clinical situations go along with a certain kind of immuno-incompetence acquired immuno-de-ficiency, immuno-suppression or temporal immuno-incompetence. Modern tumour therapy utilises a numerous of high-dose chemotherapy protocols. This induces an increasing number of long-term neutropenia (>10 days) with definitive immuno-deficiency (Chanock 1993 Hoffken 1995). In long-term neutropenia, the risk for infections rises to more than 85% (Hiddemann et al. 1996). Furthermore, after initially successful empirical antibiotic treatment, an infectious relapse occurs... 

Fig. 1. A) Ganglioglioma of the left amygdala seen on CT (arrow) causing typical temporal epilepsia to a 7-year-old male patient. B) AP view of the ganglioglioma of the left amygdala (arrow). C) Postoperative CT demonstrates the tumour bed and removed amygdaloid body (arrow)... 

Fig. 2. A) Astrocytoma of the left medial temporal lobe with large hypodense areas around the tumour. Fifty-one-year-old male patient. B) Postoperative CT demonstrates the removal of the tumour and resultant amygdalo-hippocampectomy (arrows). C)... 

Most clivus chordomas have been operated upon via a temporal craniotomy in the past, but recurrent tumours, and more recently also unoperated cases have been subjected to attempted resection by a transoral approach (Guthkelch and Williams 1967, Wood 1980, Delgado et al. 1981, Pasztor et al. 1984). Stevenson et al. (1966) used a transcervical, transclival approach in a case of chordoma. In chordomas of the upper cervical vertebrae, transoral surgery is the appropriate method (Bathia and Yadav 1965, Mullan et al. 1966, Pasztor et al. 1984). 

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