Technetium-99m complexes

Technetium-99m coordination compounds are used very widely as noniavasive imaging tools (35) (see Imaging technology Radioactive tracers). Different coordination species concentrate ia different organs. Several of the [Tc O(chelate)2] types have been used. In fact, the large majority of nuclear medicine scans ia the United States are of technetium-99m complexes. Moreover, chiral transition-metal complexes have been used to probe nucleic acid stmcture (see Nucleic acids). For example, the two chiral isomers of tris(1,10-phenanthroline)mthenium (IT) [24162-09-2] (14) iateract differentiy with DNA. These compounds are enantioselective and provide an addition tool for DNA stmctural iaterpretation (36). 

PDPH has been used in the preparation of immunotoxin conjugates (Zara et al., 1991). It has also been used to create a unique conjugate of NGF with an antibody directed against the transferrin receptor OX-26, which could traverse the blood-brain barrier (Friden et al., 1993). Labeling of antibody molecules with PDPH at oxidized polysaccharide sites followed by reduction to free the sulfhydryl has been used to form a technetium-99m complex for radiopharmaceutical use (Ranadive et al., 1993) (Chapter 8, Section 2.5). 

Holm S, Andersen AR, Vorstrup S, Lassen NA, Paulson OB, Holmes RA (1985) Dynamic SPECT of the brain using a lipophilic technetium-99m complex, PnAO. J Nucl Med 26 1129-1134 Holman BL, Johnson KA, Gerada B, Carvalho PA, Satlin A (1992) The scintigraphic appearance of Alzheimer s disease A prospective study using technetium-99m-HM-PAO SPECT. J Nucl Med 33 181-185... 

Kaul S, Boucher CA, Newell JB, Chesler DA, Greenberg JM, Okada RD, Strauss HW, Dinsmore RE, Pohost GM (1986) J Am Coll Cardiol 7 527 Kelly JD, Higly B, Archer CM, AL E (1990) Technetium-99m complexes of functionalised diphosphines for myocardial imaging. In Nicolini M, Bandoli G, Mazzi U (eds) Technetium and rhenium in chemistry and nuclear medicine, vol 3. Cortina International, Verona, p 405... 

Hexamethylpropyleneamine oxime (HMPAO) stereoisomers and their technetium-99m complexes were resolved on a 40°C Chiralcel OD column [614]. The d- and /-uncomplexed isomers were separated in 20 min using a 97/3 hexane/IPA (0.01% diethylamine) mobile phase. The ""Tc complexes were also resolved but with an 85/15 hexane/IPA mobile phase. Temperature increases from 20°C to 40°C greatly improved peak shape and resolution. A table of resolution for the Tc complexes of meso-, d- and /-HMPAO was generated for 90/10 to 0/100 hexane/IPA mobile phases. Retention times for 65/35 to 85/15 hexane/IPA were also tabulated. For all these mobile phases the retention times were under 15 min. 

Vo er A, Kunkeley H (1990) Photochemistry of Transition Metal Complexes Induced by Outer-Sphere Charge Transfer Excitation. 158 1-30 Volkert WA, Jurisson S (1996) Technetium-99m Chelates as Radiopharmaceuticals. 176 123-148... 

Waibel, R., R. Alberto, J. Willuda, R. Finnern, R. Schibli, A. Stichelberger, A. Egli, U. Abram, J.P. Mach, A. Pluckthun, and P.A. Schubiger, Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc (I)-carbonyl complex. Nat Biotechnol, 1999.17(9) 897-901. 

Vogler A, Kunkeley H (1990) Photochemistry of Transition Metal Complexes Induced by Outer-Sphere Charge Transfer Excitation. 158 1 - 30 Volkert WAJurisson S (1996) Technetium-99m Chelates as Radiopharmaceuticals. 176 123-148 Vondenhof M, see Mattay J (1991) 159 219-255 VoyerN (1997) The Development of Peptide Nanostructures. 184 1-38 Waldmann H, see Sauerbrei B (1997) 186 65 - 86 Walter C.see FessnerW-D (1997) 184 97-194 Wan P, see Krogh E (1990) 156 93-116... 

Keywords Technetium-99m Rhenium-188 Nitrido complexes Radiopharmaceuticals Imaging Therapy... 

Hexakis(2-methoxyisobutylisonitrile)technetium-99m (commonly known as [99mTc]Sestamibi) (20a), although originally developed as a radiopharmaceutical for myocardial perfusion imaging [59,60], was the first metal complex... 

PA. Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex. Nat. Biotechnol. 1999 17 897-901. 

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