Dynamic SPECT

Nakajima, K. Shuke, N. Taki, J. Ichihara, T. Motomura, N. Bunko, H. Hisada, K. A simulation of dynamic SPECT using radiopharmaceuticals with rapid clearance. J. Nucl. Med. 1992, 33 (6), 1200-1206. 

Chan, H.K. Eberl, S. Daviskas, E. Constable, C. Young, I.H. Dynamic SPECT of aerosol deposition and clearance in healthy subjects. J. Aerosol Med. 1999, 12, 135 [abst]. 

Chan HK, Eberl S, Daviskas E, Constable C, Young IH. Dynamic SPECT of aerosol deposition and mucociliary clearance in healthy subjects (abstr). J Aerosol Med 1999 12 135. 

Holm S, Andersen AR, Vorstrup S, Lassen NA, Paulson OB, Holmes RA (1985) Dynamic SPECT of the brain using a lipophilic technetium-99m complex, PnAO. J Nucl Med 26 1129-1134 Holman BL, Johnson KA, Gerada B, Carvalho PA, Satlin A (1992) The scintigraphic appearance of Alzheimer s disease A prospective study using technetium-99m-HM-PAO SPECT. J Nucl Med 33 181-185... 

Murase K, Tanada S, Fujita H, Sakaki S, Hamamoto K (1992) Kinetic behavior of Tc-99m HM-PAO in the human brain and quantification of cerebral blood flow using dynamic SPECT. J Nucl Med 33 135-143... 

Furenlid LR, Wilson DW, Chen Y-C, Kim H, Pietraski PJ, Crawford Ml, Barrett HH. Fastspect-II a second-generation high-resolution dynamic SPECT imager. IEEE Trans Nucl Sci 2004 51 631-635. 

Ventilation-peifiision scans may be helpful since a markedly abnormal pattern of patchy, matched ventilation and perfusion defects is often seen. Magnetic resonance imaging with hyperpolarized 3He, 99mTc-Technegas, and 133Xe dynamic SPECT have made possible the noninvasive reproducible measurement of structure-function relationship in small airways (10). 

Yokoe K, Satoh K, Yamamoto Y, et al. Usefulness of 99mTc-Technegas and 133Xe dynamic SPECT in ventilatory impairment. Nucl Med Commun 2006 27 887-892. Macklem PT, Mead J. Resistence of central and peripheral airways measured by a retrograde catheter. J Appl Physiol 1967 22 395-401. 

Socaciu, C. et al. (2000). Carotenoid incorporation into microsomes Yields, stability and membrane dynamics. Spectrochim. Acta A Mol. Biomol. Spect. 56(14) 2799-2809. 

Cherryman GR, Pirovano G, Kirchin MA. Gadobenate dimeglumine in MRI of acute myocardial infarction results of a phase III study comparing dynamic and delayed contrast enhanced magnetic resonance imaging with EKG, (201)T1 SPECT, and echocardiography. Invest Radiol 2002 37(3) 135-45. 

Three healthy dogs were injected with 10 mCi (370 MBq) of the labelled compound, and dynamic, static and SPECT images were taken. In the first 30 min, dynamic images were obtained with 3 s frames for the first 3 min and 1 min frames for the last 27 min. Static scintigrams were obtained at 1, 4 and 24 h post-injection SPECT images were taken 2 and 5 h post-injection (see Figs 7.10-7.12 for sample scans of normal dogs). 

The kinetic parameters of Tc-HMPAO retention in the human brain have been studied (Lassen et al. 1988), and measurements of CBF have been compared to Xe (Andersen et al. 1988). CBF was quantified using dynamic single-photon emission computer tomography (SPECT) (Murase et al. 1992). The role of SPECT with Tc-HMPAO in ischemic stroke has been evaluated (Heiss 1983 Podreka et al. 1987). Reflow hyperemia in subacute stroke has been described as luxury perfusion (Lassen 1966) and was later explained by hyperfixation of " Tc-HMPAO (Lassen and Sperling 1993). Increased regional blood flow in subacute stroke has been measured with " Tc-HMPAO (Moretti et al. 1990). The effect of acetazolamide on CBF was reported in patients with severe internal carotid artery stenosis/occlusion (Asenbaum et al. 1995), and has been studied in primates (Dormehl et al. 1997). " Tc-HMPAO SPECT was evaluated in patients with cerebrovascular disease by comparison with F-fluoromethane positron emission tomography (PET) (Heiss et al. 1990). A pattern of focal abnormalities in CBF was derived in patients with degenerative dementia (Holman et al. 1992). 

Hatazawa, J., et al.. Cerebral blood volume in acute brain infarction A combined study with dynamic susceptibility contrast MRI and 99mTc-HMPAO-SPECT. Stroke, 1999. 30(4) p. 800-6. 

Wolf RE, Morrison JM, Goldhaber MB. Simultaneous determination of Cr(lll) and Cr(VI) using reversed-phase ion-pairing liquid chromatography with dynamic reaction cell inductively coupled plasma mass spectrometry. J Anal At Spect 2007 22 1051-60. 

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