Chemogenomics approaches

Mestres J. Computational chemogenomics approaches to systematic knowledge-based drug discovery. Curr Opin Drug Discov Dev 2004 7 304-13. 

Caron PR, Mulhcan MD, Mashal RD, et al. (2001) Chemogenomic approaches to drug discovery. Curr. Opin. Chem. Biol. 5 464—470. 

Mestres J. (2004) Computational chemogenomic approaches to systematic knowledge-based drug discovery. Curr. Top. Drug Discov. Dev. 7 304—313. National Center for Health Statistics (2005) The International classification of diseases, 9th revision, chnical modification. 1CD-9-CM, 6th ed. http //www.cdc.gov/nchs/icd9.htm. 

Examples of chemogenomics approaches pursued in the academia, as well as start-up biotech and pharmaceutical setups are herein provided. 

For an excellent review of chemogenomic approaches to drug discovery, see P. R. Caron, M. D. Mullican, R. D. Mashal,... 

A very first proof that chemogenomic approaches might significantly increase the chances of success came from the target class of aspartyl proteases. During the 1980s, hundreds of man-years were spent in the search for orally available renin inhibitors, without much success. When HIV protease was recognized to be also... 

Crisman, TJ. et al. 2007. Understanding false positives in reporter gene assays in silico chemogenomics approaches to prioritize cell-based HTS data. J. Chem. Inf. Model. 47, 1319-1327. 

Rognan D. Chemogenomic approaches to rational drug design. Br. J. Pharmacol. 2007 152 38-52. 

Huang Y, Sadee W. Drug sensitivity and resistance genes in cancer chemotherapy A chemogenomics approach. Drug Discov Today 2003 8 356-63. 

Rognan, D. Chemogenomic approaches to rational drug design. 

Klabunde, T. (2006) Chemogenomic approaches to ligand design. In Rognan, D. (ed.) Ligand Design for G-protein -Coupled Receptors. Wiley-VCH, Weinheim, pp. 115-135. 

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