Tannic acid toxicity

There is no specific treatment for tannic acid toxicity. Supportive and symptomatic treatment is recommended. Liver function should be monitored in patients with gastrointestinal symptoms. 

The flavonoid quercetin suppresses growth somewhat in prairie voles, M. ochrogaster, while tannic acid, a hydrolyzable tannin, has an even stronger effect (Lindroth and Batzli, 1984). Quercetin is toxic, but does not bind with protein and, therefore, does not affect protein digestibility. Tannic acid has some effect on protein digestibility but is also toxic. 

Figure 4. Binding of a protein (hemoglobin) to several tannin extracts (tannic acid, sugar maple tannins, yellow birch tannins, quebracho tannins see 29) at various pH values. Ranges of microbial chitinase activity, NPV activity, and Bt toxicity are given. See text for discussion and references.

Rabdosia rubescens Dong Ling Cao (aerial part) Rubescensine B, oridonin, tannic acid, ponicidine, essential oils.33 This herb is toxic. Treat esophageal cancer, malignant cancer. 

Rheum officinale Baill. R. koreanum Nakai R. palmatum L. R. tanguticum Maxim R. undulatum L. Tai Huang (Rhubarb) (rhizome) Anthraquinones, chrysophanol, emodin, physcion, aloe-emodin, rhein, chrysophenol, rheum tannic acid, gallic acid, calechin, bianthraquinonyl, sennosides (R. undulatum also contains rhaponticin).1 33 236,510 This herb may be toxic. Potent laxative, antibacterial, anthelmintic, anticancer, stimulate the large intestine and increase the movement of luminal contents toward the anus, resulting in defecation. Antispasmodic, choleretic, hemostatic, diuretic, lower blood pressure, lower cholesterol level. 

Punica granatum L. China Pelletierine, isopelletierine, methyl-pelletierine, methylisopelletierine, pseudopelletierine, tannic acid, granatin.33 This herb is toxic. Treat intestinal parasties, antibacterial. 

Tannic acid (up to 1.5%) was at one time added to barium enemas in order to improve the quality of the radiological picture. Tannic acid is hepa to toxic and fulminant Uver disease very occasionally resulted. Although it was perhaps avoidable, being apparently associated mainly with higher tannic acid concentrations, mucosal damage, or a prior tannic acid washout of the bowel, the risks have made this technique obsolete. 

Tannic acid is moderately toxic by the inhalation and ingestion exposure pathways. Acute, high-dose ingestion and absorption may cause nausea, vomiting, constipation, abdominal pain, and liver damage. Severe intoxications may result in centralobular liver necrosis. 

Foraging animals consuming oak tree leaves may consume potentially toxic doses of tannic acid. Excessive chronic consumption has been shown to decrease iron and thiamin absorption as well as decreased growth rate in juvenile animals. 

In a chronic toxicity study, male and female rats were injected subcutaneously with an aqueous solution of tannic acid every fifth day for 290 days. Some dosed animals presented hepatomas and/or cholan-giomas at the end of the study (after 388 days). Although tumor incidence in the control group was rare, no clear dose-response was evident in the tannic acid treated animals. In another study, no liver damage was observed in seven male rats fed tannic acid at a dose of 60 mg kg body weight per day during 152 days. 

McArthur et al. (Ml) and others have demonstrated that extracts prepared by the tannic acid procedure are less toxic to experimental animals than those obtained by most other techniques including the variants of the kaolin-acetone method. Herbst et al. studied the accuracy of the tannic acid method by conducting recovery experiments involving the addition of the second International Reference Preparation for human menopausal gonadotropin (second IRP-HMG) to pools of normal male urine. They found that approximately 100% of the LH activity, but only 50% of the FSH activity, was recovered (H5). 

ARSENOLITE or ARSENOUS ACID or ARSENOUS ACID ANHYDRIDE or ARSENOUS ANHYDRIDE (1327-53-3) AS2O3 Noncombustible solid. Reacts, possibly violently, with acids, aluminum, aluminum chloride, chlorine trifluoride, chromic oxide, fluorine, fluorides, halogens, hydrogen fluoride, mercury, oxygen fluoride, phosphorus pentoxide, rubidium acetylide, sodium chlorate, sodium hydroxide, sulfiiric acid, tannic acid, zinc iron in solution. Contact with acids or acid mists releases toxic and flammable arsine gas. The aqueous... 

Tannic acid is a mild irritant of the skin, eyes, and respiratory tract. It is toxic by ingestion. In large doses, it may cause liver damage. No evidence is available on its carcinogenic or mutagenic effects in humans. 

Gelatin used as wall material in complex coacervation needs hardening with glutaraldehyde or formaldehyde. Both aldehydes are considered toxic to humans and must be carefully used. For this reason, several studies have been carried out to find safer cross-linking agents such as transglutaminase, tannic acid, and glycerol (Xiao et al., 2014). 

Bichel, J., and Bach, A., 1968, Investigation on the toxicity of small chronic doses of tannic acid with special reference to possible carcinogenicity, Acta Pharmacol. Toxicol., 26 41. 

Handler, P., and Baker, R.D., 1944, Toxicity of orally administered tannic acids. Science, 99 393. 

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