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Tan protein

Bdlingsley, M.L., Kincaid, R.L. (1997) Regulated phosphorylation and dephosphorylation of tan protein effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochem. J., 323, 577-591. [Pg.344]

Alkaline Proteases —derived from bacteria. They lind wide application in delergents. leather tanning, protein hydrolysis, brewing, and silver recovery from film. [Pg.306]

This forms the tough, outer layer of the egg. It consists largely of protein, the precise composition of which is uncertain. The reported absence of phenol or phenolase indicates that it is not the tanned protein sclerotin (440,640),... [Pg.177]

Gamblin TC, King ME, Dawson H, Vitek MP, Kuret J, Berry RW, et al. (2000) In vitro polymerization of tan protein monitored by laser light scattering method and application to the study of FTDP-17 mutants. Biochemistry 39 6136-6144 Goedert M (1993) Tau protein and the neurofibrillary pathology of Alzheimer s disease. Trends Neurosci 16 460-465... [Pg.663]

Buee L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR (2000) Tan protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33 95-130. [Pg.354]

Takashima A, Noguchi K, Sato K, Hoshino T, Imahori K (1993) Tan protein kinase 1 is essential for amyloid beta-protein-induced neurotoxicity. Proc Natl Acad Sci USA 90 7789-7793. [Pg.360]

Imahori K, Uchida T (1997) Physiology and pathology of tan protein kinases in relation to Alzheimer s disease. J Biochem (Tokyo) 121 179-188. [Pg.628]

It is thus necessary to confirm the existence of modified cellular function following ligand-receptor or drug-enzyme interaction. Such in vitro experiments, performed on isolated cells, either native or transfected with the protein of interest, can be undertaken for mechanistic and/or therapeutic purposes. The data depicted in Figure 3.10 illustrate the fact that, in HEK293 cells in culture, inhibition of the enzyme glycogen synthetase kinase 3(3 (GSK-3(3) decreases tan protein hyperphosphorylation, one of the anatomopathological hallmarks of Alzheimer s disease, and may thus represent a potential therapeutic approach for this disease. Alternatively, this experimental set-up can also be used for mechanistic purposes to characterize the efficacy of compounds as GSK-3 3 inhibitors. When compared to simple in vitro experiments in which the activity of the purified enzyme is measured in the presence of a... [Pg.79]

NFTs are comprised of paired helical filaments that aggregate in dense bundles. Paired helical filaments are formed from tan protein. Tan protein provides structural support to microtubules, the cell s transportation and skeletal support system. When tan filaments undergo abnormal phosphorylation at a specific site, they cannot bind effectively to microtubules, and the microtubules collapse. Without an intact system of microtubules, the cell cannot function properly and eventually dies. Overactivity of kinases such as microtubule affinity-regulating kinase, or underactivity of phosphatases could theoretically produce or prevent breakdown of abnormally phosphory-lated tan protein. NFTs are found in other dementing illnesses besides AD, and may represent a common method by which various inciting factors culminate in cell death. ... [Pg.1159]

Most primary tumors of the pineal gland originate from pineocytes, which represent modified neurons similar to retinal photoreceptor cells.Pineocytomas are typically positive for NSE, synaptophysin, neurofilament proteins, tan protein, and microtubule-associated protein-2 (MAP2) (Fig. 10.5). GFAP and S-100 protein are present in 75% and 83% of cases, respectively. [Pg.298]

Krylova, S. M., Musheev, M., Nutiu, R., Li, Y., Lee, G., Krylov, S. N. (2005). Tan protein binds single-stranded DNA sequence specifically the proof obtained in vitro with nonequUibrium capillary electrophoresis of equilibrium mixtures. FEES Lett 579, 1371-1375. [Pg.211]

J. Lee, P.A. Martic, and J.S. Tan. Protein adsorption on Pluronic copolymer-coated polystyrene particles. J. Colloid Interface ScL 131 252-266 (1989). [Pg.145]

Uses Enzyme for hydrolysis of protein, for use in detergents, industrial laundry use, food processing, tanning, protein hydrolysis, desizing textiles, wastewater treatment. [Pg.3768]

The proportion of soldiers is low (1-2% according to Gay and Calaby, 1970). They have well-developed mandibles, but also produce a highly odorous chemical secretion from the mouth which is initially colourless and fluid, but soon sets to a dark rubbery material which may immobilize enemies (Moore, 1968). This consists of j3-benzoquinone and toluquinone, which tan proteins present in the saliva turning them into dark, insoluble sclerotin. [Pg.477]


See other pages where Tan protein is mentioned: [Pg.87]    [Pg.234]    [Pg.246]    [Pg.247]    [Pg.299]    [Pg.344]    [Pg.217]    [Pg.99]    [Pg.114]    [Pg.172]    [Pg.360]    [Pg.106]    [Pg.719]    [Pg.1159]    [Pg.50]    [Pg.291]    [Pg.295]    [Pg.997]    [Pg.145]    [Pg.193]    [Pg.87]    [Pg.181]    [Pg.436]    [Pg.2407]   


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