Tachycardia INDEX

SVRI Systemic vascular resistance index VT Ventricular tachycardia... 

Gomes JA, Winters SL, Stewart D, Horowitz S, Milner M, Barreca P. A new noninvasive index to predict sustained ventricular tachycardia and sudden death in the first year after myocardial infarction based on signal-averaged electrocardiogram, radionuclide ejection fraction and Holter monitoring. J. Am. Coll. Cardiol. 1987 10 349-57. 

Tricyclic antidepressants are cardiotoxic, inducing tachycardias and an increased tendency for ventricular arrhythmias with high doses. This dose dependent cardiotoxicity gives these agents a low therapeutic index. Overdoses are characterized by cardiac conduction disturbances, hyperpyrexia, hypertension, confusion, hallucinations, seizures and coma and there is a high mortality rate in suicide attempts. Depressed patients should therefore not be given more than one week supply of these drugs. 

HeartperM (HP) and arrhythmic phenotype. HP increases significantly with age in wildtype flies (Fig. 3f). This increase is disproportionately due to an increase in the diastolic interval compared to the systolic interval. Arrhythmic events also increase significantly with age as evidenced by significant increases in the arrhythmia index. Typically the arrhythmias observed in older flies include episodes of tachycardia/fibrillation as well as bradycardia or prolonged diastolic intervals. 

Circulatory parameters The determination of circulatory parameters allows a rough calculation of the amount of blood already lost as well as optimizing the subsequent diagnostic and therapeutic measures. Loss of more than 800-900 ml blood (or less in older patients and in cases of anaemia) causes circulatory symptoms tachycardia, fall in blood pressure, decrease in both cardiac output and venous return to the heart. A central venous pressure (CVP) of < 5 cm H2O suggests an unfavourable prognosis. The Allgoewer-Burri index has proved to be a useful, objective parameter ... 

The hemodynamic effects of dofetilide 500 micrograms bd and sotalol 160 mg bd for 3-5 days have been studied in 12 patients with ischemic heart disease and sustained ventricular tachycardia (56). There were significant reductions in heart rate, mean systemic pressure, and cardiac index (-13%) with sotalol, but cardiac index increased significantly with dofetilide (11%) with no effect on heart rate or systemic blood pressure. The authors suggested that oral dofetilide could be useful in patients with ventricular tachydysrhythmias associated with impaired left ventricular function. One patient taking dofetilide reported mild dizziness and there were no cardiac dysrhythmias. 

In a retrospective view of 63 patients who received intravenous milrinone for more than 24 hours for advanced cardiac failure, the mean dose was 0.43 micro-gram/kg/minute and the mean duration of therapy 12 (range 1-70) days (14). After 24 hours of therapy there was significant improvement in pulmonary artery pressure, pulmonary capillary wedge pressure, and cardiac index. Because of the nature of the study, which was not placebo-controlled, it is impossible to be sure what events could have been attributed to the milrinone. However, the authors reported five cases of asymptomatic, non-sustained ventricular tachycardia, six of symptomatic ventricular tachycardia, and three deaths, one in ventricular tachycardia and two in heart failure. There was no difference in the incidence of these adverse events in patients who received milrinone for more than 7 days compared with the others. 

Atropine is the classic anticholinergic bronchodila-tor. It antagonizes acetylcholine, resulting in reduced intracellular cyclic guanosine monophosphate (cGMP) and smooth muscle relaxation. In horses, the therapeutic index of atropine is narrow and the duration of action is short (0.5-2.0 h). Adverse systemic effects associated with parenteral atropine administration include mydriasis, ileus, dry mucous membranes, blurred vision, excitement and tachycardia. Atropine is not suitable for routine administration to horses with recurrent airway obstruction. 

Cardiovascular Effects Thyroid hormones directly and indirectly influence cardiac function, and cardiovascular manifestations are prominent clinical consequences of thyroid disease. In hyperthyroidism, there is tachycardia, increased stroke volume, increased cardiac index, cardiac hypertrophy, decreased peripheral vascular resistance, and increased pulse pressure. In hypothyroidism, there is bradycardia, decreased cardiac index, pericardial effusion, increased peripheral vascular resistance, decreased pulse pressure, and elevation of mean arterial pressure. 

Properties Paie yei. iiq., char, disagreeabie odor soi. in chioroform, ether, carbon disuifide, oiis dens. 0.936-0.943 iodine no. 163-171 sapon. no. 190-197 fiash pt. 288.9 C ref. index 1.5030 Toxicoiogy Toxic by ing. ing. causes nausea, vomiting, cramps, diarrhea, dizziness, lethargy, disorientation iarge doses can cause fever, tachycardia, respiratory effects contact causes dermatitis... 

Patients identified as being at highest risk include those with a history of aborted cardiac arrest due to ventricular fibrillation, or sustained, poorly tolerated, ventricular tachycardia not related to a reversible cause and syncope associated with inducible ventricular tachycardia at electrophysiology testing. Patients with these conditions have up to a 30% risk of death in the first year after their index event (23-26) and many of these deaths are SCDs. 

A 22-year-old man with ulcerative colitis was started on therapy with both oral (1.6 g, twice daily) and rectal (2 g, at bedtime) mesalazine. After 20 days, the patient developed fever, chest pain and dyspnoea. Laboratory tests revealed leukocytosis, with elevation of inflammatory indexes and cardiac troponin 1. Electrocardiogram displayed sinus tachycardia, inverted T-waves in inferior and left precordial leads. Echocardiography showed a mildly dilated left ventricle, diffuse hypokinesis and mild mitral regurgitation without pericardial effusion. A diagnosis of acute myocarditis was made and mesalazine was discontinued. Cardiac symptoms improved within few days. About... 

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