Tablets coated particles

Absorption - /a pro c acid is rapidly and almost completely absorbed from the Gl tract. Absorption of the drug is delayed but not decreased by administration with meals administration of the drug with milk products does not affect the rate or degree of absorption. The bioavailability of valproate from divalproex sodium delayed-release tablets and capsules containing coated particles has been shown to be equivalent to that of valproic acid capsules. 

Tablets with polymer-coated particles 333 and PCE Dispertab (Abbott) 500 mg Rx)...

J. M. Conrad, and J. R. Robinson. Sustained drug release from tablets and particles through coating, in H. A. Lieberman and L. Lachman (eds.), Pharmaceutical Dosage Forms Tablets, Vol. 3. New York Marcel Dekker, 1982, pp. 149-221. 

A widely used method to produce multiple-unit dosage forms has been the production of sachets that contain film-coated granules. More common is the use of capsules in which enteric-coated particles are filled. A study that used radioactive tracers revealed that enteric-coated erythromycin pellets in capsules were superior to enteric-coated tablets with respect to faster action of the drug caused by a shorter passage time of the coated granules in the stomach [49-51],... 

In 1998 the first tablet containing enteric-coated particles was marketed (Losec Mups, Omeprazole-Magnesium by ASTRA, Sweden). This is a new prin-... 

Air-suspension particle/tablet coating and electronic monitoring of Pharmaceutical Manufacturing s tablet presses improved product quality and manufacturing efficiency. 

Many oral solutions are intended for pediatric administration, of which oral solution formulations are a subset of a larger choice of formulation type such as suspension, syrup, powder or microcapsules for constitution to a suspension, powder for reconstitution to a solution or suspension, solid particles (powder, coated particles, extended release, enteric-coated granules, beads) in packets or capsules to be sprinkled on food, oral powders, and chewable tablets. The broader topic of pediatric formulation development is beyond the scope of this chapter, but this chapter will cover selected oral solutions for pediatric administration. 

Tablets are defined in the Ph. Eur. as solid preparations each containing a single dose of one or more active substances [6]. Tablets are prepared by compressing tmiform volumes of particles or by another suitable manufacturing technique, such as extmsion, moulding or freeze-drying (lyophilisation). The Ph. Eur. distinguishes various types of tablets the most important being uncoated tablets, coated tablets, effervescent tablets, dispersible tablets, gastro-resistant tablets and modified-release tablets.

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