Tablet tooling special

High-Speed Rotary Tableting Machines High-speed rotary machines work with the same principles as all other rotary machines. They possess a huge number of punch and die sets and often two filling stations. Another possibility is to use punch and die sets which are able to produce several tablets simultaneously. Special tooling can be used for this purpose however this is not the subject of this chapter. As... 

A major concern of DEA special agents is the identification of the source of drug evidence. One of the methods they use to meet this requirement is through ballistics examinations of tablets. A ballistics examination, in the sense used here, is a combination of in-depth chemical analysis and tool-mark examination of tablets and capsules for the purpose of identifying the manufacturer of the drug. The technique consists of accurate measurements of size scoring, imprints, or bevels the microscopic examination of the imperfections... 

Press-coated tablets were produced on modified rotary tablet machines using special tools with hollow punches, where first an inner tablet was formed and then the outer shell was compressed in the same die ( tablet-within-a-tablet ). ... 

Control charts are an excellent analysis tool to both monitor and improve in-process performance during process development and later during production, where it is desired to follow process characteristics over time within batches or runs. The most common examples of tablet process characteristics that are measured in-process are weight, thickness, and hardness. The parameters measured need to be controllable so that adjustments can be made. During the initial runs, it is desirable to limit process adjustments to a minimum to observe the process in its natural state. Any adjustments made should be recorded and explained. Out-oflimit results should never be removed prior to performing a process capability analysis. If special cause variation is detected, then process improvements should be made to eliminate the special cause variation. 

Demands from GMP and the necessity of connecting tool sets to tablet products led to the introduction of tooling management with the help of special software (e.g., TM II from Natoli, http //natoli.com/, and Vali-Scan from Holland), where information on each individual encoded punch and die set is collected to provide a tooling life record. The software may be installed on a mobile trolley and the code on each individual tool will be checked while it is set onto the machine. 

Bricks, standard and specially shaped building blocks Naphthalene (moth) balls, / ara-chlorobenzene, chlorine cleaning tablets, swimming pool chemicals Disposable cutting tools, intricate components, steatite balls, capacitors, carbon contacts and diaphragms, metal ceramics, oxide ceramics... 

Plastic preforms, duroplastic components Brick and specially shaped parts Varied application as research tool Tablets and suppositories... 

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