T.-Valine

Kuwata, K. T Valin, L. C. Converse, A. D. Quantum Chemical and Master Equation Studies of the Methyl Vinyl Carbonyl Oxides Formed in Isoprene Ozonolysis. J. Phys. Chem. A 2003, 109, 10710-10725. 

N 052 "Helix-Coil Stability Constants for the Naturally Occurring Amino Acids in Water. VIII. Valine Parameters from Random Poly(hydroxypropylglutamine-co-t-valine)... 

The synthesis and characterization of water-soluble "random" copolymers containing t-valine with either A -O-hydroxypropyD-L-glutamine or / -(A-hydroxybutyD-L-glutamine are described, and the thermally induced helix-coil transitions of these copolymers in water are studied. The incorporation of /.-valine is found to decrease the helix content of the polymer at low temperatures and increase it at high temperatures. The Zimm-Bragg parameters o and s for the helix-coil transition in poly(t-valine) in water are deduced from an analysis of the melting curves of the copolymers. The values of s, computed for o = 1 x 1CI-4, are s 0.85 (273 K), 0.93 (293 K), 1.00 (313 K), 1.06 (333 Kl. 

Valinomycin is one of a group of compounds termed ionophores, which facilitate movement of ions across phospholipid membranes. Valinomycin has the cyclic structure f-t>valine-lactate-L-valine-hydroxy valerate-] 3. This figure shows the structure of the complex formed between valinomycin and K+. The complex is soluble in organic solvents and can pass through the phospholipid bilayer of the mitochondrial inner membrane. K+ dissociates reversibly from the complex in the aqueous solution on either side of the membrane. 

Human plasma NSTEACS 45 GC-MS Citric acid J. 4-Hydroxyproline J, Aspartic acid J, Fructose J, Lactate t Urea t Glucose t Valine t (11)... 

Shiau C Y. Baldwin JE, Byford MF, Sobcy WJ, Schofield CJ. S-L-la-AmlnoadipoyD-L cys-teinyl t>valine synthetase The order of peptide bond formation and timing of the epimeri-sacion reaction. FEES Lett 1995 358 97-100. 

Typical procedure for the synthesis of t-valine N-carboxyanhydride, (2S)-4-isopropyl-oxazolidine-2,S-dione 1205 [887, 890] L-Valine (12.9 g, 0.11 mol) and activated charcoal (0.5 g) were suspended in anhydrous THF (100 mL), and to the suspension was added diphosgene (10.0 mL, 0.083 mol). The temperature was gradually increased to 60 °C, and the mixture was maintained at this temperature for 1 h. Excess phosgene was then removed by purging with nitrogen and the suspension was filtered through Celite. The yellow filtrate was concentrated in vacuo (<40 °C). Addition of pentane (ca. 500 mL) gave crystals of L-valine NCA, which were recrystallized twice from diethyl ether/pentane (14.32 g, 91%). 

JV-Methylurea S-Methyluridine 3-Methyl-t-valine 2-(1-Methylvinyl)aniline 1-Medivl-4-vinvlcvclohexene 4-(1-Methylviiivl)-1-cyclohexene-1-carboxaldehyde, (fl)-... 

Lobucavir 39 (7.00 g, 26.39 mmol), N-Cbz-t-valine p-nitrophenyl ester (35 g) and 10.5 g Chiro-CLEC BL (immobilized enzyme) were added to a jacketed 1 L three-necked round-bottom flask equipped with an air-driven stirrer and a condenser maintained at 5°C by a circulating water bath. Acetone (490 mL) followed by 210 mL DMF were added and the reaction was carried out at 45°C. The recovered immobilized enzyme was reused. The reaction was scaled up to a 4.5 Kg batch and excess p-nitrophenyl ester of CBz-L-valine was also recovered [95]. 

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