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T-Type Calcium Channel Blockers

Several diverse structural classes of T-type calcium channel antagonists have been reported over the last decade [46,47]. This section focuses on recent literature reports of CNS T-type antagonists since 2008. [Pg.8]

Barton ME, Eberle E, Shannon HE (2005) The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil. Eur J Pharmacol 521 79-85... [Pg.49]

Cheng J-K, Lin C-S, Chen C-C et al. (2007) Effects of intrathecal injection of T-type calcium channel blockers in the rat formalin test. Behav Pharmacol 18 1-8... [Pg.50]

Choi JY, Seo HN, Lee MJ et al. (2007) Synthesis and biological evaluation of novel T-type calcium channel blockers. Bioorg Med Chem Lett 17 471-475... [Pg.50]

Clozel J-P, Ertel EA, Ertel SI (1997) Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker. J Hypertension 15(5) S17-S25... [Pg.50]

Dogrul A, Gardell LR, Ossipov MH et al. (2003) Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain 105 159-168... [Pg.50]

Todorovic SM, Meyenburg A, Jevtovic-Todorovic V (2002) Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res 951 336-340... [Pg.54]

Staurosporine Does not alter the effect of mibefradil (T-type calcium channel blocker) to dilate angiotensin ll-induced arteriolar constriction. [261]... [Pg.190]

Doddareddy MR, Jung HK, Cha JH, Cho YS, Koh HY, Chang MH, et al. 3D QSAR studies on T-type calcium channel blockers using CoMFA and CoMSIA. Bioorg Med Chem 2004 12 1613-21. [Pg.388]

Lory, R, Chemin, J. Towards the discovery of novel T-type calcium channel blockers. Expert Opin. Ther. Targets 2007, 11, 717—722. [Pg.104]

Atanassoff, P.G., Hartmannsgruber, M.W.B., Thrasher, J., Wermeling, D., Longton, W., Gaeta, R., Singh, T., Mayo, M., McGuire, D., Luther, R.R. Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain, Reg. Anesth. Pain Med. 2000, 25, 274-278. [Pg.373]

Malmberg, A.B. and Yaksh, T.L. Effect of continuous intrathecal infusion of co-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats, Pain 1995, 60, 83-90. [Pg.376]

L-type calcium channel blocker, diltiazem.T-typeCCB, pimozide Nitric oxide synthase inhibition activates L-and T-type calcium channels in afferent and efferent arterioles [235]... [Pg.188]

Mibefradil is a calcium-channel blocker that acts on the fast T-type calcium channel. It was withdrawn soon after it was launched because of identification of an increasing number of serious drug interactions caused... [Pg.860]

The LVA ai subunits are blocked by moderate to low (10 pM) concentrations of nickel and bind the channel blocker mibefradil and kurotoxin. Both compounds are not specific LVA channel blockers because they block also Cavl. x and Cav2.x channels at about tenfold higher concentration. Interestingly, the endogenous cannabinoid anandamide binds to LVA channels and stabilises the inactivated state. This effect decreases T-type calcium current and neuronal firing activities. [Pg.1304]

Bowersox, S.S., Gadbois, Th., Singh, T., Pettus, M., Wang, Y.-X., Luther, R.R. Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX - 111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain, J. Pharmacol. Exper. Ther. 1996, 279, 1243-1249. [Pg.374]

CALCIUM CHANNEL BLOCKERS PHOSPHODIESTERASE TYPE 5 INHIBITORS t hypotensive action particularly with sildenafil and vardenafil Additive effect phosphodiesterase type S inhibitors cause vasodilatation Warn patients of the small risk of postural 1 BP... [Pg.97]

CALCIUM CHANNEL BLOCKERS POTASSIUM CHANNEL ACTIVATORS t hypotensive effect Additive effect Avoid co-administration of nicorandil with phosphodiesterase type 5 inhibitors. With other drugs, monitor BP closely... [Pg.97]

The T-type or low-voltage-activated calcium channels have been identified in a variety of smooth muscle cells. They activate at low membrane potentials (around -50 mV) with a maximum around -20 mV, have a small conductance (7-8 pS with 110 mM Ba2+ as charge carrier), inactivate rapidly, and are blocked by 10-100 xM Ni2+ and a variety of compounds, including some of the organic calcium channel blockers. The biological role of the T-type channels remains to be established owing to the lack of specific blockers. [Pg.221]

See other pages where T-Type Calcium Channel Blockers is mentioned: [Pg.8]    [Pg.410]    [Pg.423]    [Pg.87]    [Pg.2336]    [Pg.374]    [Pg.8]    [Pg.410]    [Pg.423]    [Pg.87]    [Pg.2336]    [Pg.374]    [Pg.6]    [Pg.10]    [Pg.598]    [Pg.370]    [Pg.141]    [Pg.1304]    [Pg.567]    [Pg.62]    [Pg.144]    [Pg.333]    [Pg.40]    [Pg.1304]    [Pg.484]    [Pg.341]    [Pg.609]    [Pg.61]   


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