T-2 Triol

NEOSOLANIOL MONOACETATE 3 -HYDROXY-HT-2 TOXIN 15-ACETOXY-T-2 TETRAOL 3 -HYDROXY-T-2 TRIOL HT-2 TOXIN T-2 TOXIN RORIDIN A ISORORIDIN E BACCHARINOL B4 VERRUCARIN A VERRUCARIN J TRICHOVERRIN B NEOSOLANIOL ISONEOSOLANIOL... 

Tutel yan VA, Eller IQ, Sobolev VS, Avren eva LI, Rozynov BV, Bogdanova lA (1984) T-2 Triol - A New Mycotoxin Produced by Fusarium sporotrichiella. Dokl Akad Nauk SSSR 274 111-, Chem Abstr 101 3609... 

Erom SCOOP data [11], food and food raw materials were shown to be contaminated by trichothecenes (DON, NIV, FX, T-2, and HT2 toxin, T-2 triol, diacetox-yscirpenol, neosolaniol, and verrucarol). 

Schappert, K.T., Koshinsky, H.A. and Khachatourians, G.G. 1986. Growth inhibition of yeast by T-2, HT-2, T-2 triol, T-2 tetraol, diacetoxyscirpenol, verrucarol, verrucarin A and roridin A mycotoxins. J. Amer. Coll. Toxicol. 5 181-187. 

The ribavirin analogues 36 and 37 were prepared by the conversion of ethyl cyanoformate 31 to ethyl carboethoxyformimidate 32, whose reaction with formylhydrazine gave 33, which then thermally cyclized to 34. Coupling this synthon with the protected chiral chloromethyl ethers of 1,3-di-O-benzylbutane-l,2/ ,35-triol and l,3,4-tri-0-benzylbutane-l,2R,3S,4-tetrol 26 gave 35. The ester function was converted to the carboxamide moiety, and the side-chain was deprotected to give the T,2 -5eco-nucleosides 36 and 37 (88JHC651). 

Place Arcol Polyol F-3022 (100 g, 0.1 eq., 56 OH, mixed PO/EO triol from Bayer) into a suitable container. To this add distilled water (3.3 g, 0.4125 eq.), Niax Silicone L-620 (0.5 g, a silicone surfactant from OSi Specialties), and Niax C-183 (0.12 g, an amine catalyst from OSi Specialties). Thoroughly blend this mixture without incorporating air bubbles. Then add Dabco T-9 (0.25 g, stannous octoate from Air Products) and mix again. The T-9 must be added last because it is quite water sensitive, so its exposure to the water-containing polyol blend should be kept to a minimum. To this polyol blend, quickly add Mondur TD-80 (42.6 g, 0.4868 eq., a mixture of 80% 2,4-TDI and 20% 2,6-TDI isomers from Bayer) and immediately stir at 3000 rpm for 5 s. Quickly pour the reaction mixture into a suitable container such as a 1-qt paper or plastic cup and allow the foam to free-rise. The stir blade may be wiped or brushed clean. 

Triazole-based fungicides, 13 306, 595 Triazoles, 26 145, 9 288-289 Triazone, 2 640 s-Triazine-2,4,6-triol, S 200 Tribaloy T-800... 

Tuz Golu (lake), 5 784 Tversky similarity, 6 8 T vessicant agent, 5 816 physical properties, 5 817t Twaron fiber, 13 373 Tween surfactants, 24 150 12-membered ring macrolides, 15 272, 275t 2,6-TDI, reaction with a polyether triol, 25 459. See also Toluene diisocyanate (TDI)... 

Fujino, A., Asano, M., Yamaguchi, H., Shirasaka, N., Sakoda, A., Ikunaka, M., Obata, R., Nishiyama, S. and Sugai, T., Bacillus subtilis epoxide hydrolase-catalyzed preparation of enan-tiopure 2-methylpropane-l,2,3-triol monobenzyl ether and its application to expeditious synthesis of (R)-hicalutamide. Tetrahedron Lett., 2007, 48, 979. 

Assuming that the synthesis, i.e. the reaction of the tetra-acid chloride with racemic t/zreo-aminotriol will result into a statistical distribution, the probability of formation of all isomers should be identical. These isomers are illustrated schematically in Fig. 20 where the configuration (2R,3S) of the 3-amino-butane-1,2,4-triol is abbreviated as a and 2S,3R) as b . 

Cembra-2-7-11 -triene-4-6-diol, (lS-2-trans-4S-6R-7-trans-ll-trans) P1 T Cembra-2-7-1 l-triene-4-6-diol, a f T460 Cembra-2-7-12 (20-triene-4-6-11 -triol), (lS-2-trans-4S-6R-7-trans) Pl Cembra-2-7-dien-l 2-one, 4-6-dihydroxy-20-nor, (lS-2-trans-4S-6R-7-trans) pl T33 Cembra-2-7-diene-4-6-diol, 11-12-epoxy,... 

In only one case was the triple bond differently functionalized a terminal acetylene group was converted by hydroboration into a for-mylmethylene (OHC-CH2-) grouping. In this way, 2-deoxy-DL-erythro-pentose (2) was obtained10 from en/t/iro-4-pentyn-l,2,3-triol (1). 

L. Den Drijver, C. W. Holzapfel, J. M. Koekemoer, G. J. Kruger, and M. S. Van Dyk, Regioselective oxidation of carbohydrates triols facile synthesis of 2,3-O-isopropylidene-/i-D-t/jreo-hexo-2,4-diulo-pyranose and l,2-0-isopropylidene-/i-D-t/jreo-hexo-2,5-diulo-pyranose, Carbohydr. Res., 155 (1986) 141-150. 

Both tributylstannyl ethers and dibutylstannylene acetals of terminal triols yield in most cases the product of reaction with 1,2-diols in preference to other hydroxyl groups, as shown in Figs. 47 and 48. Figure 47 also illustrates the tendency of t-butylchlorodimethylsilane to react with terminal 1,3-diols in preference to terminal 1,2-diols.87 Figure 48 shows that the preference for reaction at terminal oxygen atoms is considerably stronger than the preference for reaction next to unsubstituted centers, discussed in the previous section. As the numerous examples in Table IX demonstrate, this selectivity is maintained over a wide range of structural features. 

More sterically demanding ketones can influence the selectivity of dioxolane formation. For example, butane-1,2,4-triol reacts with 3-pentanone43 44 or 3,3-dimethoxypentane45 46 to give a mixture of the dioxolane 2SA and dioxane 28 5 in a ratio of 45 1 respectively [Scheme 3.28]. Enhanced preference for the dioxolane isomer is also observed in the reaction of 2-0-p-methoxybenzyl-t-threitol (29 1) with 3-pentanone [Scheme 3.29].47 48... 

Malinowski and T. Urbanski [60] advanced a suggestion that a hydrogen bond can exist between the nitro and the hydroxy group in -nitro alcohols. This was based on the experimental fact that 2-nitropropane-I,3-diol (1) formed cyclic acetalS l,3-dioxane derivatives (II) and ketals with great difficulty, while on the contrary the triol 2-hydroxymethy -2-nitro-propane-l,3-diol (III) forms the corresponding cyclic acetal (IV) and ketal with great ease. 

From a trimethylsilylated triol /i-MeOC6H4CHO, TMSOTf, CH2CI2, -1 T C, 5h, 96% yield. ... 

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