T- B-cell interaction

Shivdasani, R.A., and Thomas, D.W. (1988) Molecular associations of IA antigens after T-B cell interactions. J. Immunol. 141, 1252-1260. 

Vercelli, D., Jabara, H.H., Atai, K.I. and Geha, R.S. (1989b). Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J. Exp. Med. 169, 1295-1307. 

Mourad W, Scholl P, Diaz A, Geha R, Chatila T The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell interaction. J Exp Med 1989 170 2011—2022. 

Evidence for genetic restrictions in cooperative T-B cell interactions 145... 

In this complementation experiment, we have demonstrated that one or more Ir genes that control T-B cell interactions are localized in the K end of the H-2 gene complex. Thus, DBA/2 KLH-primed T cells cooperated with (C3H X C3H.OH)Fi and (C3H x C3H.OL)Fi DNP-primed B cells to make a secondary response to DNP-KLH, but not with C3H or (C3H x C3H.A)Fj DNP-primed cells. It must be emphasized that the carrier-primed DBA/2 T cells are histoincompatible with each of these B cell populations for both non-H-2 and H-2 determinants. The presence of foreign histocompatibility determinants provided by the C3H parent does not therefore prevent successful physiological T-B cell cooperation in Fj hybrids which have at least one complement of and genes derived from C3H.OH or C3H.OL parents. However, complementation with and genes derived from the... 

The evidence to date indicates that the cell-interaction genes involved in T-B cell interactions map in the / region, more specifically in the I-A and/or I-B subregions. The location of Cl genes involved in macrophage-T cell interactions and those possibly involved in T-T interactions are not as clearly mapped as yet. 

The process controlled by H-linked Ir genes is probably intimately concerned with the regulation of T-B cell interactions, and the gene codes for the molecule or part of the molecular complex responsible for this process. 

A major effort in studies on the mechanism of T-B cell interactions has been focused on the identification and characterization of various biologically active... 

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