Systems biology chemical genomics

Chemical genomics represents a holistic approach since in principle the small molecules could interact with the whole proteome either through direct binding interaction or indirectly as a downstream effect through the signaling network. Since the cell response is the overall consequence of the interactions initiated by the small molecules, chemical genomics is closely associated with systems biology and network theory (Yildirim et al., 2007). 

The chemical genomics/proteomics methods are complemented with a much broader discipline, called chemogenomics, which builds a relationship with the system biology and investigates the matching of the chemical and biological space integrating experimental and in silico approaches. 

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