Systemic illness

A generalized systemic illness may accompany HIV seroconversion (Cooper et al. 1985). Guillain-Barre syndrome (GBS) (Piette et al. 1986), unilateral (Wiselka et al. 1987) or bilateral facial palsies (Wechsler and Ho 1989), bibra-chial palsy (Calabrese et al. 1987) and sensory neuropathy (Denning 1988) have been reported to occur during this process, usually within 1-2 weeks of the acute febrile illness. Spinal fluid analysis may show a mild to moderate mononuclear pleocytosis and a mild increase in protein levels. The precise relationship to HIV viral load in the cerebrospinal fluid (CSF) or plasma is unknown (Brew 2003). There is no proven therapy, but most patients recover spontaneously without any treatment. 

Imaging studies, such as x-ray and magnetic resonance imaging (MRI), can identify osteomyelitis. Blood cultures should be obtained from all patients with signs and symptoms of systemic illness. Deep tissue cultures may help to direct therapy. Bone also maybe sent for culture in cases of osteomyelitis. Superficial cultures are unreliable and should be avoided. 

Mild 2 Presence of at least two manifestations of inflammation (purulence or erythema, pain, tenderness, warmth or induration), but any cellulitis/erythema extends no more than 2 cm around the ulcer, and infection is limited to the skin or superficial subcutaneous tissues no other local complications or systemic illness... 

T. pallidum rapidly penetrates intact mucous membranes or microscopic dermal abrasions, and within a few hours, enters the lymphatics and blood to produce systemic illness. During the secondary stage, examinations commonly demonstrate abnormal findings in the cerebrospinal fluid (CSF). As the infection progresses, the parenchyma of the brain and spinal cord may subsequently be damaged. 

The first episode is a systemic illness associated with the vesicular lesions, may last up to 21 days, usually has an uncomplicated course of infection, and in severe cases may require hospitalization. Several agents have been found to be effective during this period (Table 77-3).28,29 At the cited dosages, these agents have had excellent outcomes with regard to lesion healing time, viral shedding, and loss of pain. Common adverse effects are nausea, headache, and diarrhea. 

Toxins are primarily hazardous through inhalation, ingestion, and broken, abraded, or lacerated skin (e.g., penetration of skin by debris). A small number of toxins, such as the mycotoxins, produce skin lesions and systemic illness through skin and eye exposure. Toxins may also be dissolved in select solvents and delivered as dilute solutions that pose a percutaneous hazard. 

The metabolic encephalopathies comprise a series of neurological disorders not caused by primary structural abnormalities rather, they result from systemic illness, such as diabetes, liver disease and renal failure. Metabolic encephalopathies usually develop acutely or subacutely and are reversible if the systemic disorder is treated. If left... 

The first priority on assessing the patient with pneumonia is to evaluate the adequacy of respiratory function and to determine whether there are signs of systemic illness, specifically dehydration or sepsis with resulting circulatory collapse. 

In the headache evaluation, diagnostic alarms should be identified. These include acute onset of the first or worst headache ever, accelerating pattern of headache following subacute onset, onset of headache after age 50 years, headache associated with systemic illness (e.g., fever, nausea, vomiting, stiff neck, and rash), headache with focal neurologic symptoms or papilledema, and new-onset headache in a patient with cancer or human immunodeficiency virus infection. 

In humans VCD is considered to be a mild to moderate skin irritant, although occasional instances of marked irritation have been reported. In one case severe vesiculation of the skin of both feet occurred when a worker wore shoes previously contaminated with VCD. A single case of allergic contact dermatitis has also been reported in a worker whose gloves were permeable to VCD. Systemic illness in humans has not been reported in association with exposure. ... 

Mainly because the molecular mechanism of these pathological changes has not been sufficiently studied, therapy of asthma, pulmonary illnesses, and other respiratory system illnesses are generally aimed at preventing and relieving symptoms that accompany the disease. 

Respiratory system illness, as a rule, is accompanied by a cough— a protective mechanism by which foreign substances, irritants, and mucous are discharged from the respiratory tract. 

Drugs for Treating Respiratory System Illnesses, Pages 311-321... 

In the process of testing, color deviations are expressed in the C1ELAB system or Lite equivalent polar LHC system. Ill either case Lesled samples must fall within acceptable ranges or limits established versus a standard by the pigment manufacturer and accepted by the pigment user. 

Price, F. P. and Wendorff, J. H. Transitions in mesophase forming systems. Ill, Transformation kinetics and textural changes in cholesteryl nonanoate. J, Phys. Chem. 76, 276 (1972)... 

The low T3 syndrome is induced by a decrease in the production of plasma T3 as well as the clearance of plasma rT3 and is observed in several clinical situations such as starvation, systemic illness and the use of certain drugs [115]. In fasting [70] and illness [108] the abnormal thyroid hormone metabolism appears to result from a defective liver uptake and, therefore, a decreased supply of T4 and rT3 for intracellular deiodination. In other conditions such as treatment with PTU or propranolol [116], the defect appears localized in the type I deiodinase itself leading to a decline in T3 formation and rT3 breakdown. 

Possible risk factors include trauma, unusual physical exercise, surgery, severe systemic illness, severe dieting, dietary excess, alcohol, drugs, status epilepticus, psoriasis, renal failure, lead intoxication, Down s syndrome, high purine diet, cytolytic therapy, myeloproliferative and lymphoproliferative disorders. Mr KT has several risk factors which increase his chances of developing gout ... 

---