Synthetic repertoire

Benzophenones are usually attached as a complete photophore. Apart from the standard chemical techniques, new C-C coupling procedures extend the synthetic repertoire. However, in some cases direct benzoylation (e.g., Friedel-Crafts acylation) of aromatic or heteroaromatic rings can provide an easy access to BP or BP-like photophores (Scheme 4D) [38,39]. 

Over the years many different synthetic strategies have been employed to construct ET compounds or multiporphyrin systems and the available synthetic repertoire is continuously expanding110. 

The purpose of the chapter is to highlight the increasing range of possibilities open to the chemist by including new techniques of electrochemical fluorination into his synthetic repertoire as a result of advances in the field over the past five to ten years. 

Cyclohexadiene and singlet oxygen form (103). Most of the important synthetic approaches for 1,2-thiazines use a fragment in which the S-N bond already exists. Syntheses via [4 + 2] cycloadditions constitute a major part of the synthetic repertoire for this class of compounds (CHEC-II(6)370). Thus, pentadiene with TsNSO gives (104) and perfluoro-l,2-thiazine (105) is prepared by the cycloaddition of thiazyl fluoride (FSN) and perfluoro-1,3-butadiene CF2 = CFCF = CF2 (79CC35). 

Prospero, T D, Hoogenboom, H. R, Nissim, A., Cox, J P L., Harrison, J. L., Zaccolo, M., Gherardi, E, and Winter, G. (1994) Isolation of high-affinity human antibodies directly from large synthetic repertoires. EMBOJ 13, 3245-3260. 

Isolation of high affinity human antibodies directly from large synthetic repertoires. EM BO J 13,3245—3260. 

Hoogenboom, H. R and Winter, G. (1992) By-passing immunization, human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro J Mol Biol 227, 381—388. 

Hopefully, this chapter has provided the reader with an appreciation of the diverse range of chemical transformations which may be achieved based upon the chemistry of radical ions. Over the past fifteen years, neutral free radical processes have enjoyed a transition from mechanistic curiosities to their present status as important tools in the synthetic repertoire. It is likely that the same will hold true in future years for radical ions. 

In recent years, radical cyclization processes, particularly those of the 5-hexenyl system, have become very important tools within the synthetic repertoire of... 

Desiderio, A., Franconi, R., Lopez, M., Villani, A. E., Viti, F., Chiaraluce, R., et al. (2001) A semi-synthetic repertoire of intrinsically stable antibody fragments derived from a single-framework scaffold. J. Mol. Biol. 310, 603-615. 

Hoogenboom HR, Winter G, Bypassing immunisation human antibodies from synthetic repertoires of germ line VH-gene segments rearranged in vitro, J. Mol. Biol., 227 381-388, 1992. 

The bienzymatic transformation of aldehydes and HCN in the presence of an oxynitrilase and a nitrilase is a useful addition to the synthetic repertoire, provided that the coproduction of amide can be avoided. 

The Diels-Alder reaction has both enabled and shaped the art and science of total synthesis over the last few decades to an extent which, arguably, has yet to be eclipsed by any other transformation in the current synthetic repertoire. 

The synthetic repertoire of solid-phase organic chemistry has been growing rapidly in the past years and has expanded its scope in the complexity of compounds synthesized on solid phase. However, so far only a medium percentage of chemistry in solution has been transferred into reliable solid-supported protocols [64-67]. Two ISIS-based databases... 

Although the synthetic repertoire of SPOC is growing rapidly, there are still opportunities for further development of reactions on solid phase, e.g., Friedel-Crafts reactions. Those reactions that have been applied to solid phase in a reliable and robust manner, are listed below. 

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