Synthetic polyisoprene rubbers pharmaceutical applications

Jenke [73] studied the extractabihty of aniline, diphenylguanidine, dedenzyl-amine, and triisopropanolamine from a synthetic polyisoprene rubber similar to the material used in pharmaceutical applications. Rubber samples were autoclaved (121 °C) in contact with water or NaCl 0.9% solution for lh.Table 33 presents the concentration of each compound in solution after the extraction procedure using 2g rubber material. Extraction profiles ranged between 1.64 and 3.73 mg/L, with the exception of diphenylguanidine, whose extraction yield reached 11.76 mg/L. 

As for natural rubber the most important single outlet is in tyre production but benefits may be obtained in the manufacture of products as diverse as elastic bands, bridge bearings, conveyor belts and pharmaceutical goods. Certain specific attributes of synthetic polyisoprenes have made them attractive to manufacturers. For example, the lack of non-rubbers allows higher resistivity values to be reached in electrical applications and the low modulus provides easy extensibility and therefore comfort for items such as respirator masks and bathing hats. 

High c/.T-polyisoprenes also find application in other pharmaceutical products. For catheters where extremely fine calendered film is used for the small inflators which prevent movement or dislodgement of this surgical insert, the synthetic polymer offers control of the tolerance of the rubber sheet used and can be calendered much thinner than natural rubber. 

Elastomers are used in a wide range of industrial, transportation, domestic, construction and aerospace end-applications. The major consumer of both natural and synthetic rubber is the tyre industry. Five types natural rubber (NR), styrene butadiene rubber (SBR), polybutadiene, polyisoprene and the butyl (and halobutyl) rubbers are used in massive quantities around the world. Smaller applications for rubbers include conveyor belting, footwear, pharmaceutical closures, plant lining, hoses, extruded goods, flooring, power cables, gaskets and seals, and many, many other applications. 

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