Synthetic Physical Data

More recently 233) it has been reported that cross-linked polystyrene containing imidazole ligands did not provide a support rigid enough to prevent dimerization, and that the p-oxo dimer was benzene extracted from oxygenated tetraphenyl porphyrin iron(ll), Fe(TPP), which had been attached to the modified polystyrene. A discussion of model synthetic porphyrins, from which definitive structural and other physical data are obtained, is given in section V.C. 

Snieckus and his group members [104] used the known domino Sonogashira/ Castro-Stephens reaction [105, 106] for the synthesis of the natural product pli-cadin (6/1-209), this having been isolated from Psorelia plicata in 1991 [107]. In this synthesis, Pd°-catalyzed reaction of the alkyne 6/1-210 and the iodobenzene derivative 6/1-211 in the presence of Cul led to the furan 6/1-212, which was transformed into 6/1-209 via 6/1-213 (Scheme 6/1.54). There are some discrepancies of the physical data of the natural and the synthetic product thus, it might be possible that the natural product has a different structure. It should also be mentioned that the... 

Wu et al. isolated mukonidine (54) along with its O-methyl derivative, clausine L (39) (see Scheme 2.9) (59). However, the spectroscopic and physical data of Chakraborty s O-methylmukonidine were not identical with those of clausine L (59,78). Based on the agreement of the data of synthetic mukonidine with those of Wu s mukonidine (59), it was concluded that Chakraborty s mukonidine (78) may have a different structure (79-81). The UV, IR, and H-NMR spectra of mukonidine... 

Nowadays any chemistry endeavor produces a massive amount of physical data. Measurements range from routine operations performed daily in synthetic laboratories to very sophisticated measurements with very expensive apparatuses. Only a very small part of the data is effectively used. Most individual data points are never published, and the published data are often provided in forms not suitable for automatic processing. 

At the step of the 1,2-reduction of the hydroxymethylenone 231, the allyl alcohol 232q was also obtained. Trehalostatin (the C5-epimer of trehazolin) (224) was then synthesized from this allyl alcohol 232a according to the synthetic route to trehazolin (223) [188]. The physical data, including the H-NMR spectrum, of trehalostatin (224), were quite close to those of trehazolin (223) itself, but the inhibitory activities of this compound towards trehalases were much weaker than those of trehazolin (223). As a result, the argued stereochemistries of the aminocyclitol moiety of trehazolin (223) and trehalostatin (224) were determined to be [IR-(lo , 2/3, 3a, 4/3, 5/3)] and [li -(la, 2a, 3a, 4/3, 5/3)] by these synthetic studies, respectively ( Scheme 37). 

The compound 6,12-dihydro-6-hydroxy-cannabidiol described in the present application has so far not been either synthetically produced or used as an intermediate for the production of irans-delta-9-tetrahy-drocEmnabinol. One reference to it in the literature (see Garrett et al., J. Pharm. Sci. 67 (1978) pages 27-32) only relates to the analytical chromatographic trace detection of one of a number of many other products of decomposition of delta-9-THC in an acidic solution. The compound has therefore not been produced in preparative quantities nor used for any sort of reactions. Furthermore the physical data of the compound have not been described previous to the present application. 

Compound Synthetic method Yield (%) M.p. (°C) or b.p. (°C/mmHg) Physical data Reference... 

Compounds Synthetic Yield M.p. (°C) Physical data Reference... 

Reviews dealing with synthetic methods in 1,4,2-dithiazine chemistry have been published.1,2 74 75 For a compilation of 1,4,2-dithiazines reported until 1986 together with their physical data see ref 2. 

The earlier reviews on heterophospholes in general include anellated azaphospholes as well, though in a limited manner [3-6], A comprehensive review on anellated heterophospholes covers the literature up to 1994 and includes a detailed list of the compounds and their physical data reported till then [12], In another review, analogy between the synthetic methods and reactions of anellated heterophospholes and their non-phosphorus analogues has been highlighted [13]. A review is limited to the analogy between the synthesis of indolizines and phosphaindolizines [14]. The synthesis of anellated heterophospholes from 2-substituted cycloiminium salts forms the subject matter of two reviews [15,16]. Some recent advances in the chemistry of anellated azaphospholes have been published in a recent review [7],... 

Table 4-174 Physical Data of Synthetic Lubricants (Suppliers data).

Watson (1980), Watson et al. (1981) and TiUey and Andersen (1981b) prepared bis(pentamethylcyclopentadienyl) ytterbium, lutetium, neodymium and samarium chlorides and iodides. Some physical data of these compounds together with those of the other complexes with substituted cyclopentadienyl ligands are given in table 8. The following synthetic methods have been used ytterbium metal is oxidized by CjMejI in the presence of Lil in ether to give, via CjMejYbl, the complexes shown in eq. (20). In the absence of Lil, only dimeric pentamethylcyclopentadiene was isolated. 

Ephedra spp. roots are known as major source of ephedrine and derivatives alkaloids, but this plant species also contains an imidazole derivative, feruloylhistamine (12), which was identified in methanolic extract of the drug in 1983 [19, 20]. After column chromatography and crystallization procedures, feruloylhistamine was characterized by and NMR and mass spectroscopy. A molecular ion peak was observed at miz 287 consistent to a C15H17N3O3 fragment, and the NMR spectrum revealed signals for aliphatic and aromatic carbons and also one carbonyl group. The synthetic derivative was also obtained and afforded the same physical data as the natural compound [19]. 

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