Ligand imidazole-containing

A simple and direct approach to new imidazole containing ligands is the modification of commercially available imidazoles. Unfortunately, only a limited number of substituted imidazoles is available and most of them are not ideally substituted for further modification because they have only plain alkyl or phenyl substituents. An example of this approach is the synthesis of 3-aminopropylimidazole9 and 3-hydroxy-propy I imidazole10 from urocanic acid... 

From the standpoint of modeling Type I copper proteins,4,5,59,60 a variety of imidazole-based ligands containing thioether sulfurs and imidazole groups have been synthesized.61,62 The structures and spectroscopic properties of their copper(II) complexes (51)-(53) and (55)-(60) were investigated.65,79-82 To characterize apical copper(II)-thioether bonding, the complex (51) was... 

Figure 14.15 CDI can be used to activate hydroxyl-particles in organic solvent and then the intermediate reactive imidazole carbamate brought into aqueous solution for coupling amine-containing ligands.

Flexible imidazole-containing tripodal ligands [e.g., l,3,5-tris(imidazol-l-yl-methyl)benzene and l,3,5-tris(imidazol-l-ylmethyl)-2,4,6-trimethylbenzene (1)]... 

Imidazole-containing compounds have been utilized as reagents for various synthetic transformations. A convenient access to substituted allyl enol carbonates was established through the reaction of ketone enolates with the complex of allyl l//-imidazole-l-carboxylates 74 and boron trifluoride etherate <07JOC9372>. Relatively mild and highly efficient Cul-catalyzed /V-arylation procedures for imidazoles with aryl and heteroaryl bromides or chlorides have been developed in the presence of ligands 75 and cesium carbonate <07JOC2737>. a, -Unsaturated 2-acyl imidazoles 76 are an alternative and practical class of dienophiles for the DNA-based catalytic asymmetric Diels-Alder reaction in... 

Imidazol-containing SBs have received much attention in the last decades as possible models for metalloenzymes. Thus, a series of asymmetrical tetradentate N2OS SBs (38,39) containing both imidazole and thioether functions derived from the precursors 4-[(2 -aminoethyl)thiomethyl (5-methylimidazole, 2-[(2 -aminoethyl)thiomethyll-benzimidazole and either sal (or derivatives), acetophenones, or acac have been prepared.103-106 These ligands behave as mono- or dianionic... 

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