Carbohydrate synthetic

Esterification. The hydroxyl groups of sugars can react with organic and inorganic acids just as other alcohols do. Both natural and synthetic carbohydrate esters are important in various apphcations (1,13). Phosphate monoesters of sugars are important in metabohc reactions. An example is the enzyme-catalyzed, reversible aldol addition between dibydroxyacetone phosphate [57-04-51 and D-ylyceraldehyde 3-phosphate [591-57-1 / to form D-fmctose 1,6-bisphosphate [488-69-7],... 

C.-H. Wong and co-workers iu D. Horton, L. D. Hawkius, G. J. McGarvey, eds.. Trends in Synthetic Carbohydrate Chemistry, ACS Symposium Series,... 

Rg. 60. Schematic representation of a fully synthetic carbohydrate-based vaccine. 

S. Sirois, M. Touaibia, K.-C. Chou, and R. Roy, Glycosylation of HIV-1 gpl20 V3 loop Towards the rational design of a synthetic carbohydrate vaccine, Curr. Med. Chem., 30 (2007) 3232-3242. 

Toyokuni, T., and Singhal, A.K. (1995) Synthetic carbohydrate vaccines based on tumour-associated antigens. Chem. Soc. Rev. 24, 231-242. 

This chapter outlines the development, achievements and limitations of glycosyla-tion methods that rely on Cl-hemiacetal donors and Cl-O-acyl donors. These are among the simplest glycosyl donors to prepare in standard O-glycosylation reactions. As such, developments in the use of these donors constitute valuable advances in the field of synthetic carbohydrate chemistry. 

The main efforts in the field of synthetic carbohydrate chemistry have been focusing on the development of new glycosylation methodologies and convergent strategies for... 

Fig. 4 Enthalpy-entropy plot obtained by ITC measurement on a family of related microbial lectins interacting with natural and synthetic carbohydrates.

The incorporation of KDO appears to be a vital step in LPS biosynthesis, and, indeed, in growth of the Gram-negative bacteria. Therefore, the immunochemistry, biochemistry, and synthetic carbohydrate chemistry involving KDO has become of increasing interest in pharmaceutical research. As the significant body of literature published... 

TRENDS IN SYNTHETIC CARBOHYDRATE CHEMISTRY Table III. Continued... 

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