Synergies agonists

Remington TL, Digiovine B. Long-acting beta-agonists anti-inflammatory properties and synergy with corticosteroids in asthma. Curr Opin Pulm Med. 2005 11 74-78. 

Stone LS, MacMillan LB, Kitto KF, Limbird LE, Wilcox GL (1997) The a2A adrenergic receptor subtype mediates spinal analgesia evoked by 02 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 17 7157-65... 

Keefe KA, Gerfen CR (1995) D1-D2 dopamine receptor synergy in striatum effects of intrastriatal infusions of dopamine agonists and antagonists on immediate early gene expression. Neuroscience 66 903-913. 

At a cellular level, the purported sorafenib editors should be assayed using the renal cancer cell line RCC-786-O and NRVMs (neonatal rat ventricular monocytes). In RCCs, the sorafenib/WBZ 4 combination yields agonistic synergy, marked by an increased inhibition of cell proliferation when compared to sorafenib-alone levels at equivalent bulk concentrations (Fig. 12.5a) The dose-dependent inhibition is greater than the Loewe-additive values [20, 21] (Fig. 12.5b). By contrast, the sorafenib-induced recruitment of the pro-apoptotic pathway in cardiomyocytes should be impaired by the downstream interference of WBZ 4 through JNK inhibition (Fig. 12.3a). Consequently, cytosolic release of... 

It should be noted that almost all fundamental types of adverse event have been described, including those mentioned above. These include agonist-antagonist interaction, protein-binding competition, metabolic adaptation and pharmacodynamic synergy. 

Lees GJ, Leong W (1994) Synergy between diazepam and NBQX in preventing neuronal death caused by non-NMDA agonists. Neuroreport 5 2149-2152... 

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