Agonist-antagonist interactions

It should be noted that almost all fundamental types of adverse event have been described, including those mentioned above. These include agonist-antagonist interaction, protein-binding competition, metabolic adaptation and pharmacodynamic synergy. 

Lew, M. J., and Angus, J. A. (1996). Analysis of competitive agonist-antagonist interactions by nonlinear regression. Trends Pharmacol. Sci. 16 328-337. 

Muscarinic Receptor Structure and Agonist/Antagonist Interactions... 

The basic methodical approach in receptor studies is that of quantitative estimations of the relationship between drug concentration and effect evoked, by quantitative analysis of agonist—antagonist interaction and by studying structure-action relationships. 

A. Miklavc, D. Kocjan, J. Mavri, J. Roller and D. Hadzi, On the fundamental difference in thermodynamics of agonist and antagonist interactions with P-adrenergic receptors and the mechanism of entropy-driven binding. Biochem. Pharmacol., 40 (1990) 663-669. 

These X-ray structures provide a wealth of information about the interactions of agonists, antagonists, and allosteric modulators with the glutamate receptor subunit... 

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