Suxamethonium bromide

SUtilains [ban, inn, usan] (BAX 1515 Travase ) is an ENZYME derived from Bacillus subtilis. It is a proteolytic enzyme used for wound debridement in moist conditions, suxamethonium chloride [ban. inn] (succinyichoiine chloride [usan] suxamethonium bromide [ban] succinoylcholine Scoline Quelicin Anectine ) is a bistrimethylethanaminium derivative, a NICOTINIC CHOLINOCEPTOR AGONIST, a (depolarizing) NEUROMUSCULAR BLOCKING AGENT, which can be used as a SKELETAL MUSCLE RELAXANT in anaesthesia relaxant. Its action is short-lived due to hydrolysis by plasma cholinesterase, suxamethonium bromide suxamethonium chloride. 

It is certain that pancuronium is but the first of a series of steroids of this type There is l or example, need for an agent with its favourable properties but with the brevity ot action of suxamethonium. Achievement of this aim may not be too distant since quaternary derivatives of the alkaloid conessine, possessing (in cats at least) the required characteristics have recently been described [75], and dacuronium bromide is now under intensive study by the team responsible for the development of pancuronium. 

Disposition in the Body. Choline is a metabolite of suxamethonium chloride and suxethonium bromide. 

Alcuronium Chloride Benserazide Bethanidine Bretylium Tosylate Carbachol Debrisoquine Dibromopropamidine Dihydrostreptomycin Guanethidine Guanoxan Hexylcaine Homatropine Hydroxystilbamidine Hyoscine Kanamycin Mepenzolate Bromide Metformin Obidoxime Chloride Pancuronium Bromide Pentamidine Pentapiperide Propamidine Pyrithidium Bromide Suxamethonium Chloride Suxethonium Bromide Thiamine... 

Suxamethonium chloride, 998 Suxamethonium iodide, 998 Sux-Cert, 998 Suxethonium bromide, 999 Suxinutin, 600 SVC, 313... 

Examples Suxamethonium chloride Suxethonium bromide Decamethonium bromide. 

The two onium groups present in decamethonium bromide are situated at a distance of 15 A which incidentally compares very closely to that of suxamethonium chloride. Decamethonium cannot be hydrolysed by chloinesterase and hence exerts a much more prolonged effect. 

Distigmine A patient taking the anticholinesterase distigmine bromide for urinary retention underwent ECT facUitated by suxamethonium 1 mg/kg [10 ]. Paralysis after administration of suxamethonium lasted 30 minutes and plasma cholinesterase activity was below the reference range. Reduced plasma cholinesterase activity leads to reduced clearance of suxamethonium and prolonged action, a predictable interaction. 

Isono S, lizuka K, Fukami G, Shinozuka N, lyo M, Nishino T. Ubretid (distigmine bromide) taken to treat urinary retention prolongs the effect of suxamethonium. J Anesth 2008 22(3) 337. 

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