Obidoxime chloride

Obidoxime chloride as insecticide, 2, 516 Obtusilactone H NMR, 4, 578 Occidentalol synthesis, 1, 472 Octaaza[14]annulenes bis w-excessive, 7, 717 Octacoral... 

USP2996510, 59MI20900) all exhibit cholinesterase reactivation. Obidoxime chloride (52), based on the 4-aldoxime, has a similar function. 

FIGURE 5.13 Autocatalytic reaction of obidoxime chloride with k = 3.27 x lO mLfmg-wk)-1 (a) concentration vs. time and (b) rate vs. time. [Graph reconstructed from data by Rubnov et al., J. Pharm. Pharmcol., 51, 9 (1999).]... 

Cholinesterase inhibition, the mechanism whereby a number of insecticides and nerve gases function, may be reversed by acid salts of pyridine-2-carbaldehyde oxime (51). The chloride (61JPS109, 64USP3155674), iodide (57USP2816113) and methanesulfonate (58USP2996510. 59MI20900) all exhibit cholinesterase reactivation. Obidoxime chloride (52), based on the 4-aldoxime, has a similar function. 

Dose. Obidoxime chloride has been given parenterally in doses of 250 mg. 

Alcuronium Chloride Benserazide Bethanidine Bretylium Tosylate Carbachol Debrisoquine Dibromopropamidine Dihydrostreptomycin Guanethidine Guanoxan Hexylcaine Homatropine Hydroxystilbamidine Hyoscine Kanamycin Mepenzolate Bromide Metformin Obidoxime Chloride Pancuronium Bromide Pentamidine Pentapiperide Propamidine Pyrithidium Bromide Suxamethonium Chloride Suxethonium Bromide Thiamine... 

Obidoxime chloride 250mg IM elicited a different profile of adverse effects in humans, including a hot and tight feeling in the orofacial region, along with numbness. In addition, a cold... 

Christenson I (1972). Hydrolysis of obidoxime chloride (Toxogonin ). III. Kinetics in neutral and alkaline solution. Acta Pharm Suec, 9, 309-322. 

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