Sustained-release of Peptide and Protein Drugs

Buserelin acetate reduces the plasma levels of endogenous sex hormones to a castrate level through down-regulation, when administered continuously or daily. These paradoxical and pharmacological effects are utilized in the treatment of endocrine-dependent diseases such as endometriosis and precocious and uterine 

Inhibitory Effects of CyDs on Abnegate Formation of Polypeptides 

The propensity of polypeptide and protein drugs to form reversible and irreversible aggregates in solution is of great concern as it may lead to the loss of desired pharmacological activity, immunogenic reactions, and unacceptable physical appearance in long-term therapeutic system. To overcome these drawbacks, several approaches have been proposed, including the use of amphiphatic excipients, chemical modification, and site-directed mutation [104]. 

G -o D G,-y-CyD GUG yGyD Man yCyD DM yCyD HP yCyD Glucose Maltose Trehalose Refolding CA KH 

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