Suspending agents tragacanth

Incompatible with halides anionic emulsifying agents and suspending agents tragacanth starch talc sodium metabisulfite sodium thiosulfate disodium edetate silicates aluminum and other metals amino acids ammonia and ammonium salts sulfur compounds rubber and some plastics. 

The antimicrobial activity of phenylmercuric salts may be reduced in the presence of anionic emulsifying agents and suspending agents, tragacanth, starch, talc, sodium metabisul-fite, sodium thiosulfate, disodium edetate, and silicates... 

Common suspending agents are poly(vinyl alcohols) of various molecular weights and degrees of hydrolysis, starches, gelatin, calcium phosphate (especially freshly precipitated calcium phosphate dispersed in water to be used in the preparation), salts of poly(acrylic acid), gum arabic, gum tragacanth, etc. 

D. Oral suspensions Additives are very similar to C, only flavorings are included along with suspending agents such as the gums, tragacanth, acacia, and bentonite. 

Farley CA, Lund W. Suspending agents for extemporaneous dispensing evaluation of alternatives to tragacanth. Pharm 1976 216 562-566. 

Tragacanth gum is used as an emulsifying and suspending agent in a variety of pharmaceutical formulations. It is used in creams, gels, and emulsions at various concentrations according to the application of the formulation and the grade of gum used. 

Extemporaneous preparation of suspensions of drugs available commercially only in other dose forms is widely practised in hospital pharmacy, particularly for paediatric use. Dmgs such as acetazolamide, amiodarone and mercaptopurine are examples. In such formulations, alternatives to traditional suspending agents such as tragacanth should be examined. The ideal suspending agent should ... 

It is an effective suspending agent for pharmaceuticals and is used in conjunction with acacia as an emulsifier, the tragacanth imparting a high stmctural viscosity while the gum arabic adsorbs at the oil/water interface. It is also used in spermicidal jellies, acting by immobilising spermatozoa and as a viscous barrier. 

Viscosity is possibly the most important single consideration for evaluating gum tragacanth. It can be called a yardstick for judging quality and serves as a guide to its behavior as a suspending agent, stabilizer, or emulsifier (16, 17). 

The high viscosity of tragacanth solutions makes it useful in pharmaceutical practice as a suspending agent in aqueous mixtures containing resinous tinctures (such as jalap and myrrh) and heavy insoluble powders. Glycerite of tragacanth is a useful excipient to bind pill masses. 

Use of gum tragacanth dates back thousands of years ago as an emulsifier, viscosity builder, and suspending agent [3]. It has been recognized as generally safe in food stuffs at the 0.2-1.3% level in the USA since 1961. It has been coded as E413 in the list of additives by the Scientific Committee for Food of the European Community [4]. 

Gum tragacanth has the ability to extensively modify the rheology of aqueous media even at low concentrations. Thus, it has foxuid uses as suspending agent, stabilizer, emulsifier [4] and sustained release agent [56,61,62]. It has also been studied for topical applications [63]. 

Recent studies evaluated Sesamum indicum L., sesame (Pedaliaceae) gum for its useful properties in the drug industry as a binder/hydrophilic polymer in the formulation of sustained release paracetamol granules and tablets, compared with standard binders Arabic gum, gelatin, and sodium carboxymethylcellulose [277] for the intestinal delivery of antifilarial drug diethylcarbamazine tablets [278] as an accessible, cost-effective and eco-friendly suspending agent in a pediatric pharmaceutical suspensions, compared with Arabic gum and tragacanth [279]. 

Gum tragacanth is used as a suspending agent for many water-insoluble products, where it prevents the settling out of these materials. It is used as a base for jelly lubricants, tooth pastes, medicinal oil emulsions of steroids and fat-soluble vitamins, and insect repellents. 

Farley, C.A., 1976, Suspending Agents for Extemporaneous Dispensing Evaluation of Alternatives to Tragacanth , The Pharmaceutical Journal, June 26, pp 562-566. 

Powdered Tragacanth Gum Type E-1 Powdered Tragacanth Gum Type W Tragacanth Gum Ribbon No. 1 NF FCC suspending agent, barium sulfate... 

Tragacanth Gum Ribbon No. 1 NF FCC suspending agent, metal burnishing compds. 

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