Surgical site infection treatment

Chronic infections in contrast tend to be focal infections, limited in size, that wax and wane for long durations and are only partially destructive to tissues. The strategies of a single-cell, mobile, free-floating bacterium versus those of a community of bacteria encased in a self-secreted protective matrix (biofilm) are radically different and may one type of infections "chronic." Biofilm is intrinsically resistant to host immunity, antibiotics, and biocides, different treatment strategies will be required. Chronic infections such as chronic wounds, surgical-site infections, and infected implants will yield only to repetitive evaluation and multiple simultaneous therapies that require much persistence from the physician. 

Chamberlain RS, Culshaw DL, Donovan BJ, Lamp KC. Daptomycin for the treatment of surgical site infections. Surgery 2009 146(2) 316-24. 

The most widely used formulation of nitrofurazone is the soluble dressing , a preparation suitable for surgical as well as dermatological infections. In burns, it is applied for treatment as well as for the prevention of infections. Pre-operative application is advised for skin grafting whereas nitrofurazone is used post-operatively on grafts as well as on donor s sites. Due to the high water-solubility there will be no interference with successful takes . 

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