Surface enhanced laser desorption/ionization time-of-flight

Diamond DL, Zhang Y, Gaiger A, et al. Use of ProteinChip array surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) to identify thymosin beta-4, a differentially secreted protein from lymphoblastoid cell lines. J. Am. Soc. Mass Spectrom. 2003 14 760-765. 

In a related approach, arrays with different types of surface chemistries such as hydrophobic, hydrophilic, anionic, and affinity are used to absorb certain protein groups from biological or patient samples. The chip-absorbed proteins are then directly detected by surface-enhanced laser desorption/ionization time-of-flight MS (SELDl-TOF MS) (Issaq et al. 2002). The resulting protein masses can be used in pattern analysis and thereby provide a useful diagnostic tool. 

Amyloid P peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry evidence of novel biomarkers in Alzheimer s disease. 

SELDI-TOF surface enhanced laser desorption ionization time-of-flight... 

SURFACE-ENHANCED LASER-DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY... 

Merchant, M. Weinberger, S.R. Recent Advancements in Surface-enhanced Laser Desorption/Ionization-Time of Flight-Mass Spectrometry," Electrophoresis 21(6), 1164-1177 (2000). 

Streckfus, C. F., Bigler, L. R., and Zwick, M. The use of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to detect putative breast cancer markers in saliva A feasibility study. J Oral Pathol Med, 35 292-300,2006. 

Schaub, S., Wilkins, J., Weiler, T., Sangster, K., Rush, D., and Nickerson, P. Urine protein profiling with surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry. Kidney Int, 65 323-332, 2004. 

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