Summary of Studies Discussed in the

SUMMARY OF STUDIES DISCUSSED IN THE 1996 NATIONAL RESEARCH COUNCIL REPORT... 

Near the end of this study guide you will find additional sections that may help you to study for the final examination in the course. The SUMMARY OF SYNTHETIC METHODS lists the important ways to synthesize each class of compounds discussed in the text. It is followed by the SUMMARY OF REACTION MECHANISMS. Both of these sections have references to appropriate portions of the text, in case you feel that further review is necessary. Finally, you will find two lists of sample test questions. The first deals with synthesis, and the second is a list of multiple-choice questions. Both of these sets should help you prepare for examinations. 

Summary of PDHS Structure, The information concerning the solid-state structure of PDHS that has been obtained from the studies discussed in the previous sections is summarized in the schematic drawings of Figure 19, although the complete crystal structure of PDHS has not been reported yet. The unit cell of the well-ordered phase I is monoclinic, with a and b dimensions of 1.375 and 2.182 nm, respectively, and the angle y is 88° (9). The c dimension is 0.400 nm (26), which implies that the backbone has an all-trans conformation. The side chains are arranged in a direction nearly perpendicular to that of the backbone, with a nearly all- mn5 conformation. 

Summaries of the tests and studies performed and used in the development of the final EDP for AEA s SILVER II technology package are discussed in the following sections. 

The review will begin with a brief description of the progress in the field over the past three decades and will provide a perspective of how the electrochemical measurements have developed in this growing field. This will be followed by a theoretical section which provides some general theoretical principles behind the technique. A description of some of the new microscopic approaches to modelling the nonlinear source currents from metal surfaces will also be presented. An experimental technique section will describe the details involved in making a variety of surface SH measurements. A summary of the results of experimental studies conducted in the past few years on single crystal electrode surfaces in solution will follow. The discussion will draw upon related work performed in UHV and studies on polycrystalline surfaces where comparisons are appropriate. For a more comprehensive discussion of these later two topics, the reader is referred to several other recent reviews [7,9]. 

The factors discussed in the preceding paragraphs indicate the fundamental importance which HPLC procedures are likely to occupy in connection with the pursuit of occupational health chemistry in the future. Accordingly, a consideration of HPLC from this viewpoint is timely. This document provides a brief summary of general HPLC methodology as well as a description of specific procedures for the analysis of selected compounds or groups of compounds which are currently important in occupational health hazard research studies and evaluations. 

In addition to the discussion of the elements for evaluation in the individual studies section of the TSD, a section entitled "Data Adequacy and Research Needs" is included in the text of the TSD. A summary of the data-adequacy discussion is also included in the derivation summary tables in the appendix of the TSD and in the summary section of the TSD. The text of the TSD relates the studies used to derive or support the derivation of the AEGL values to the discussion of the adequacy of the available data. Brief summaries of this discussion are included in the summary and derivation summary tables. The data-adequacy section also presents and integrates the weight of evidence by considering all information as a whole for each AEGL developed. In addition to considering the elements for evaluation as relevant in the discussion, a number of other factors must be considered. They include repeatability of experiments between laboratories, consistency of data between experiments and laboratories, types and number of species tested, variability of results between species, and comparison of AEGL values with the valid... 

As discussed in the toxicology guidance document for FCSs (Table 2.3), the recommended toxicology information includes both an overall safety narrative and a comprehensive toxicological profile for the ECS and each of its constituents. The safety narrative summarizes all the information relevant to a conclusion that the intended use of the FCS is safe. The comprehensive toxicological profile consists of summaries and critical evaluations of all the available toxicological information pertinent to the safety evaluation for each substance. This information includes reviews and conclusions of toxicity studies on the FCS and other relevant substances that are either published in the literature or available elsewhere. 

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