Future Outlook and Summary

This work was supported by a grant from the NIH (R24 CA 92862) and an unrestricted gift from Philips Medical. 

Doyle TC, Bums SM, Contag CH. In vivo bioluminescence imaging for integrated studies of infection. Cell Microbiol 2004 6 303 317. 

Hardy J, Edinger M, Bacbmann MH, Negrin RS, Fathman CG, Contag CH. Bioluminescence imaging of lymphocyte trafficking in vivo. Exp Hematol 2001 29 1353 1360. 

Contag CH, Bachmann MH. Advances in in vivo bioluminescence imaging of gene expression. Annu Rev Biomed Eng 2002 4 235 -260. 

Contag PR, Olomu E4, Stevenson DK, Contag CH. Bioluminescent indicators in living mammals. Nat Med 1998 4 245 247. 

Over the past several decades, research in the field of palladium catalysis has resulted in the development of a myriad of transformations that provide access to saturated nitrogen heterocycles. Many of these transformations effect the formation of several bonds, and/or proceed with good to excellent levels of stereocontrol. Despite the many advances made in this field, discoveries of new reactivity are still being reported with great frequency, and this promises to remain a fruitful area of research for many years to come. In particular, the development of new palladium catalysts will likely lead to improvements in the scope of existing transformations, and will also open up new reaction pathways that can be applied to unsolved problems in heterocydic chemistry. 

5 The first example of intramolecular Pd-mediated N-arylation was reported by Boger, who employed this reaction for constmction of the aromatic core of lavendamydn methyl ester. See  

22 (a) For related transformations of alkynes that afford five-membered nitrogen heteroqfcles, see Kozawa, Y. and Mori, M. (2002) Tetrahedron Lett., 43, 1499-1502 (b) Kimura, M  

61 Muniz, K, Hdvebnann, C.H., StreufF, J., and Campoz-Gomez, E. (2008) Pure Appl. Chem., 80, 1089-1096. 

There is growing interest in the biomedical research community in using small molecules to dissect signaling networks based on protein-protein interactions. The 

Caspase 9 Release Assay Small Molecule Dlsruptor of XIAP SIR 3-Caspase 9 Interactions 

XIAP has b en shown to MikI to BasfiBEfl- S and inhibit ils ability to Induce apoptosie 

XIAP imtacidAieta wuuid bind tc XIAP thereby raleaeing BBEpm-9 and indjclng cell death 

Ca paW VfBn cleave fluoicEcant probe allowing measurable cespas 9 activity 

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Summary and future outlook for ONP in molecular crystals Acknowledgements... 

SUMMARY AND FUTURE OUTLOOK SYNTHONIC ENGINEERING PARTICLE PASSPORT AND THE FUTURE OF THE DRUG PRODUCT DESIGN... 

Why Chloromethane 205 The Surface Acidity of T -Alumina 206 Three Types of Surface Site Become Four 208 Interaction of Methanol with the TJ-Alumina Surface 211 The Interaction of Anhydrous HCI with T -Alumina 211 Temperature-Programmed Reaction Studies 213 Summary and Future Outlook 213... 

XI. SUMMARY AND FUTURE OUTLOOK A. Dislocation-Based Theories... 

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