Sulforaphane phase 1 enzyme induction

Ritz SA, Wan J, Diaz-Sanchez D (2007) Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extractAm J Physiol 292(1 ) L33-L39. 

Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomark Prev 200i i0 949-954. 

The attention of breeders is now increasingly turning to micronutrient content and density. As an example, so-called produced by crossing a normal broccoli variety. Marathon, with from Sicily. The level of the isothiocyanate sulforaphane in the cross was 10-fold higher than in conventional broccoli, and the induction of quinone reductase, a phase 2 enzyme, was increased almost 100-fold [9]. Acceptance trials have revealed no detrimental taste or sensory characteristics, and the product is expected to reach the marketplace within the next few years. Developments such as this will, hopefully, serve to make the consumer aware of the health benefits of such foods as part of an overall balanced diet and may go some way to prepare the ground for a broader acceptance of genetically manipulated produce. 

Munday, R. and Munday, C.M. 2004. Induction of phase II detoxification enzymes in rats by plant-derived isothiooyanates comparison of allyl isothiocyanate with sulforaphane and related compounds. Journal of Agricultural andFood Chemistry, 52(1), 1867-71. doi 10.1021/ jf030549s. 

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