Sulfobetain acrylamide

Sulfobetaine methacrylate Poly(sulfobetaine acrylamide) Nguyen, Baggerman, Paulusse, Van Rijn, and Zuilhof (2011)... 

Poly(sulfobetaine methacrylate-co-A -isopropyl-acrylamide) water 2009CH2... 

DADMAC 13C, for example, can be readily polymerized imder these cyclopolymerization conditions to yield PolyDADMAC in which a structure composed of 5-membered A -heterocycles predominates. 13C will readily polymerize at 35°C employing ammonium persulfate as the initiator. 13C is readily copolymerized with other diallyl monomers, with acrylamide monomers such as 28C or diacetone acrylamide, or quaternized 1C. Extensive reviews of cyclopol5mieriza-tion and cyclocopolymerization can be found in Reference 188. Recent examples of cyclocopolymerization with sulfobetaine (14C) and carboxybetaine (15C) diallyl ammonium monomers are given in References (188-191). 

The free radical polymerizations of 3-[(2-Acrylamido-2-mefliyl propyl)dimethylammonio]-l-propanesulfonate with acrylamide and/or acrylic acid, and 3-(i Tj -diallyl-i /-methylammonio)-l-propanesulfonate with A, iV diailyl-i, iV-dimethyl ammonium chloride or AT,A/-diallyl-iV,-methyl amine have been studied. Reactivity ratios indicate random incorporation of comonomers. Molecular weights range from 3.0 x 10 to 15.1 x 10 g mol for the acrylamido-based copolymers and from 2.2 x 10 to 6.0 x 10 g mol for the cyclocopolymers. Second virial coefficients and viscosities decrease as sulfobetaine content increa s for each of the copolymers. A transition from polyelectrolyte to polyampholyte behavior is observed with added NaCl for those copolymers with sulfobetaine monomer incorporation greater than 40 mol%... 

Polymer Synthesis. Acrylamide-based Polymers, Acrylamide-based polymers were prepared in an 0.5 M NaCl aqueous solution at 30 C using KPS as the free radical initiator. Total monomer concentration was held constant at 0.45 M and the pH adjusted so that all monomers were in die ionized form. Reactions were terminated at <60% conversion by precipitation in acetone. The polymers were fiirther purified by dialysis against deionized water. In the following discussion, the number appended to the polymer series is representative of the mol% of the respective sulfobetaine incorporated into the polymer (See Tables 1,2,3, and 4). 

In this chapto, we have illustrated the effects of molecular architecture of polysulfobetaines on solution behavior under specilBc environmental conditions of pH, added electrolytes, and polymer concentration. The nature of the comonomer and amount of incorporation of the sulfobetaine within the polymer chain dictate the polymer solubility and solution behavior. Polyampholyte behavior is realized for acrylamide-based systems containing the sulfobetaine moiety. Polyelectrolyte behavior is coupled with polyampholyte behavior for cyclopolymers containing >40mol% sulfobetaine. Incorporation of the sulfobetaine monomer hinders hydrophobic association for the pH responsive copolymers of series TV at low degrees of ionization. 

On the other hand, several polymers of acrylic acid (55), acrylamide (56), and (meth)acrylate with sulfobetain (57) or uracil side group (58) which undergo UCST (not LCST) phase separation, have been studied [209-214], as... 

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