Sugar tumor

Ribalta T, Lloreta J, Munne A, et al. Malignant pigmented clear cell epithelioid tumor of the kidney clear cell ( sugar ) tumor versus malignant melanoma. Hum Pathol. 2000 31 516-519. 

Zamboni G, Pea M, Martignoni G, et al. Clear cell sugar tumor of the pancreas a novel member of the family of lesions characterized by the presence of perivascular epithelioid cells. Am J Surg Pathol. 1996 20 722-730. 

Tanaka Y, Ijiri R, Kato K, et al. HMB-45/Melan-A and smooth muscle actin-positive clear-cell epithelioid tumor arising in the ligamentum teres hepatis additional example of clear-cell sugar tumors. Am J Surg Pathol. 2000 24 1295-1299. 

Clear Cell Neoplasm/Sugar Tumor/PEComa... 

PEComa (sugar tumor) versus SCA HMB-45 and SMA are positive in PEComa, whereas the absence of such reactivity and immunolabeling for CKs and EMA is typical for SCA. 

It is of interest to note that the anomeric effect directs the boron substituent into the a-configuration in the case of mannose, despite the considerable steric demand. NMR studies in solution indicate that the usual 4Q conformation of the pyranose is retained, with the boron substituent in the axial position. Depending on the sugar moiety, tumor uptake is observed when the compounds are given to tumor-bearing animals. Accumulation is, however, only transient, and within a fairly short time, the boron is lost from the tumor, and from other tissues. Even at... 

N-Acetvlneuraminic Acid Aldolase. A new procedure has also been developed for the synthesis of 9-0-acetyl-N-acetylneuraminic acid using the aldolase catalyzed reaction methodology. This compound is an unusual sialic acid found in a number of tumor cells and influenza virus C glycoproteins (4 ). The aldol acceptor, 6-0-acetyl-D-mannosamine was prepared in 70% isolated yield from isopropenyl acetate and N-acetyl-D-mannosamine catalyzed by protease N from Bacillus subtilis (from Amano). The 6-0-acetyl hexose was previously prepared by a complicated chemical procedure (42.) The target molecule was obtained in 90% yield via the condensation of the 6-0-acetyl sugar and pyruvate catalyzed by NANA aldolase (Figure 6). With similar procedures applied to KDO, 2-deoxy-NANA and 2-deoxy-2-fluoro-NANA were prepared from NANA. 

Potentially beneficial roles of imino sugars as chemotherapeutic compounds, based on their complex interactions with such vital and essential metabolic processes as glycosphingolipidoses, tumor development, or the immune system have also been recently reviewed408 and have remained hot topics. 409 11... 

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