Succinic acid bioproduction

Different Methods of Malic Acid 9.4 Succinic Acid Bioproduction 164... 

The considerable industrial potential for succinic acid bioproduction was proposed in the 1980s. It can substitute for maleic acid or maleic anhydride as a platform chemical. A succinic acid-derived chemical intermediate has the potential to replace chemicals such as benzene and other petrochemical-based intermediates (Zeikus et al., 1999 Fumagalli, 2007). Succinic acid has also been the most reputed potential chemical building block among a few other bio-based chemicals (Bozell and Petersen, 2010). The most remarkable future application of succinic acid is its polymers with a potential market value of 25 million tons/year. Some important reasons for the inclusion of succinic acid in a list of the 10 top future chemicals include Ihe following ... 

SUCCINIC ACID BIOPRODUCTION TABLE 9.3 Microorganisms Investigated for Succinic Acid Production 169... 

Cukalovic, A. and Stevens, C.V. (2008) Feasibility of production methods for succinic acid derivatives a marriage of renewable resources and chemical technology. Biofuels, Bioproducts and Biorefining, 2 (6), 505-529. 

The downstream purification of succinic acid is also key for the fermentation process, which has a cost of about 60-70% of that of the total bioproduction process (Baniel and Eyal 1995). The separation and purification of succinic acid from the fermentation broth has been reviewed in the literature (Zeikus et al. 1999). 

Cheng, K.K., Zhao, X.B., Zeng, J., et al., 2012. Biotechnological production of succinic acid current state and perspectives. Biofuels Bioproducts Biorefining 6,302-318. 

Lin, C.S.K., Luque, R., Clark, J.H., Webb, C., Du, C., 2012. Wheat-based biorefining strategy for fermentative production and chemical transformations of succinic acid. Biofuels, Bioproducts and Biorefining 6, 88—104. 

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